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川芎嗪抑制肾细胞癌的迁移和侵袭。

Ligustrazine Inhibits the Migration and Invasion of Renal Cell Carcinoma.

作者信息

Zhang Xufeng, Wang Junfu, Cao Yanhua, Li Kalin, Sun Chao, Jiang Wen, Xin Qian, Wang Jue, Qi Tonggang, Liu Shuangde, Luan Yun

机构信息

Department of Renal Transplantation, The Second Hospital of Shandong University, Jinan, PR China.

College of Pharmacy, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, PR China.

出版信息

J Kidney Cancer VHL. 2023 Jan 14;10(1):1-8. doi: 10.15586/jkcvhl.v10i1.232. eCollection 2023.

DOI:10.15586/jkcvhl.v10i1.232
PMID:36713028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9846118/
Abstract

Ligustrazine is a Chinese herb ( approved for use as a medical drug in China. Recent evidence suggests that ligustrazine has promising antitumor properties. Our preliminary results showed that ligustrazine could inhibit the growth of human renal cell carcinoma (RCC) cell lines. However, the complicated molecular mechanism has not been fully revealed. Therefore, the purpose of this study to investigate the mechanism of ligustrazine resistance in human RCC cells. Cell proliferation, migration, invasion, and colony-formation ability of RCC cells A498 were detected by MTT assay, clonal formation rates, and transwell chamber assay in . The expression of epithelial-mesenchymal transition (EMT)-related proteins were analyzed using western blot test. The effect of ligustrazine on the growth of A498 cells in nude mice was investigated in . Our results showed that ligustrazine could significantly inhibit the proliferation, migration, and invasion of A498 both in and . Western blot analysis showed that the expressions of EMT-related, N-cadherin, snail, and slug proteins were significantly decreased in A498 in the ligustrazine treatment group. This study indicated that ligustrazine could significantly inhibit the malignant biological behaviors of RCC cell lines, possibly by inhibiting the EMT process.

摘要

川芎嗪是一种中草药（在中国被批准用作药物）。最近的证据表明川芎嗪具有良好的抗肿瘤特性。我们的初步结果显示川芎嗪能够抑制人肾细胞癌（RCC）细胞系的生长。然而，其复杂的分子机制尚未完全揭示。因此，本研究旨在探讨人RCC细胞中川芎嗪耐药的机制。通过MTT法、克隆形成率和Transwell小室法检测RCC细胞A498的细胞增殖、迁移、侵袭和集落形成能力。采用蛋白质免疫印迹法分析上皮-间质转化（EMT）相关蛋白的表达。在……中研究了川芎嗪对裸鼠体内A498细胞生长的影响。我们的结果表明，川芎嗪在体外和体内均可显著抑制A498细胞的增殖、迁移和侵袭。蛋白质免疫印迹分析显示，川芎嗪处理组A498细胞中EMT相关的N-钙黏蛋白、蜗牛蛋白和蛞蝓蛋白的表达显著降低。本研究表明，川芎嗪可能通过抑制EMT过程显著抑制RCC细胞系的恶性生物学行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/404b6a3668c3/JKCVHL-10-001-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/12cae3ff48d2/JKCVHL-10-001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/f9acbed6d216/JKCVHL-10-001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/2e2ce984926f/JKCVHL-10-001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/cf245caae77e/JKCVHL-10-001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/3ece0d1bd767/JKCVHL-10-001-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/404b6a3668c3/JKCVHL-10-001-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/12cae3ff48d2/JKCVHL-10-001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/f9acbed6d216/JKCVHL-10-001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/2e2ce984926f/JKCVHL-10-001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/cf245caae77e/JKCVHL-10-001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/3ece0d1bd767/JKCVHL-10-001-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/9846118/404b6a3668c3/JKCVHL-10-001-g006.jpg

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J Nat Prod. 2021 Dec 24;84(12):3161-3168. doi: 10.1021/acs.jnatprod.1c00618. Epub 2021 Nov 21.
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Ligustrazine activate the PPAR-γ pathway and play a protective role in vascular calcification.川芎嗪激活PPAR-γ通路并在血管钙化中发挥保护作用。
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Novel therapeutic strategies: targeting epithelial-mesenchymal transition in colorectal cancer.
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CORO6 Promotes Cell Growth and Invasion of Clear Cell Renal Cell Carcinoma via Activation of WNT Signaling.CORO6通过激活WNT信号通路促进肾透明细胞癌的细胞生长和侵袭。
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