Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Department of Physiology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Nutr Cancer. 2023;75(3):785-794. doi: 10.1080/01635581.2023.2173258. Epub 2023 Jan 30.
The anti-inflammatory properties of glucosamine and chondroitin suggest that they may have potential effects in cancer prevention. We performed this meta-analysis to assess the protective function of glucosamine and/or chondroitin intake against cancer risk. We searched the PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) databases. The odds ratio (OR), corresponding to the 95% confidence interval (95% CI), was used to assess the association between chondroitin and/or glucosamine intake and cancer risk. Thirteen studies met the inclusion criteria, with 1,690,918 participants and 55,045 cancer cases. Overall, chondroitin and/or glucosamine intake was associated with a lower risk of colorectal cancer (OR = 0.91, 95% CI, 0.87-0.94) and lung cancer (OR = 0.84, 95% CI, 0.79-0.89). Subgroup analysis supported the protective effect of different SYSADOAs (chondroitin and/or glucosamine) intake. However, the protective effect was not observed in the only chondroitin intake group and in the NSAIDs group. Our meta-analysis found that the intake of glucosamine and/or chondroitin decreased the risk of colorectal and lung cancers. Moreover, NSAIDs use may have a synergistic protective effect.
氨基葡萄糖和硫酸软骨素具有抗炎特性，这表明它们可能对癌症预防有潜在作用。我们进行了这项荟萃分析，以评估氨基葡萄糖和/或硫酸软骨素摄入对癌症风险的保护作用。我们检索了 PubMed、Embase、Web of Science 和中国国家知识基础设施（CNKI）数据库。使用比值比（OR）及其 95%置信区间（95%CI）来评估硫酸软骨素和/或氨基葡萄糖摄入与癌症风险之间的关联。符合纳入标准的有 13 项研究，共纳入 1690918 名参与者和 55045 例癌症病例。总体而言，硫酸软骨素和/或氨基葡萄糖摄入与结直肠癌（OR=0.91，95%CI，0.87-0.94）和肺癌（OR=0.84，95%CI，0.79-0.89）风险降低相关。亚组分析支持不同 SYSADOAs（硫酸软骨素和/或氨基葡萄糖）摄入的保护作用。然而，仅硫酸软骨素摄入组和 NSAIDs 组未观察到保护作用。我们的荟萃分析发现，摄入氨基葡萄糖和/或硫酸软骨素降低了结直肠癌和肺癌的风险。此外，NSAIDs 的使用可能具有协同保护作用。
