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抗 TIF1γ 抗体阳性皮肌炎伴纳武利尤单抗治疗晚期食管鳞癌 1 例报告并文献复习

Anti-TIF1γ antibody-positive dermatomyositis associated with nivolumab administration in a patient with advanced oesophageal squamous cell carcinoma: A case report and literature review.

机构信息

Department of Cardiology, The Jikei University School of Medicine, Tokyo, Japan.

Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.

出版信息

Mod Rheumatol Case Rep. 2023 Jun 19;7(2):416-421. doi: 10.1093/mrcr/rxad007.

Abstract

We report a case of anti-transcriptional intermediary factor 1γ antibody-positive dermatomyositis following nivolumab treatment. The patient was successfully treated with pulse steroid therapy and high-dose intravenous immunoglobulin, followed by oral glucocorticoid treatment. Immune checkpoint inhibitors, such as nivolumab, may induce not only myositis as an immune-related adverse event but also dermatomyositides as a paraneoplastic syndrome by distracting immune tolerance. Differentiating between pathologies is warranted if patients develop myositis after immune checkpoint inhibitor administration.

摘要

我们报告了一例纳武利尤单抗治疗后抗转录中介因子 1γ 抗体阳性皮肌炎。该患者经脉冲类固醇治疗和大剂量静脉注射免疫球蛋白治疗后成功,随后口服糖皮质激素治疗。免疫检查点抑制剂,如纳武利尤单抗,不仅可能通过干扰免疫耐受而导致肌炎作为免疫相关不良事件,而且可能导致皮肌炎作为副肿瘤综合征。如果患者在免疫检查点抑制剂给药后出现肌炎,则有必要对其进行病理区分。

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