Department of Cardiology, The Jikei University School of Medicine, Tokyo, Japan.
Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
Mod Rheumatol Case Rep. 2023 Jun 19;7(2):416-421. doi: 10.1093/mrcr/rxad007.
We report a case of anti-transcriptional intermediary factor 1γ antibody-positive dermatomyositis following nivolumab treatment. The patient was successfully treated with pulse steroid therapy and high-dose intravenous immunoglobulin, followed by oral glucocorticoid treatment. Immune checkpoint inhibitors, such as nivolumab, may induce not only myositis as an immune-related adverse event but also dermatomyositides as a paraneoplastic syndrome by distracting immune tolerance. Differentiating between pathologies is warranted if patients develop myositis after immune checkpoint inhibitor administration.
我们报告了一例纳武利尤单抗治疗后抗转录中介因子 1γ 抗体阳性皮肌炎。该患者经脉冲类固醇治疗和大剂量静脉注射免疫球蛋白治疗后成功,随后口服糖皮质激素治疗。免疫检查点抑制剂,如纳武利尤单抗,不仅可能通过干扰免疫耐受而导致肌炎作为免疫相关不良事件,而且可能导致皮肌炎作为副肿瘤综合征。如果患者在免疫检查点抑制剂给药后出现肌炎,则有必要对其进行病理区分。