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尼日利亚阿布贾一家三级医疗中心为病情稳定的人类免疫缺陷病毒患者提供基于社区的抗逆转录病毒药物补充服务的结果:一项为期3年的回顾。

Outcome of Community-Based Antiretroviral Drug Refill among Stable Human Immunodeficiency Virus Patients Accessing Care at a Tertiary Center in Abuja, Nigeria: A 3-Year Review.

作者信息

Kwaghe V G, Abubakar I, Kumtong N, Rapnap L, Jamda M

机构信息

Department of Internal Medicine, University of Abuja Teaching Hospital, Gwagwalada, Abuja.

Department of Community Medicine, University of Abuja Teaching Hospital, Gwagwalada, Abuja.

出版信息

West Afr J Med. 2023 Jan 30;40(1):67-71.

Abstract

INTRODUCTION

Community-based delivery of antiretroviral therapy (ART) is an innovative approach that delivers HIV treatment services closer to the people, removing logistical barriers to clinic access, thereby improving ART uptake and retention in care. The United States Emergency Plan for AIDS Relief (PEPFAR) program in Nigeria involved community-based private sector pharmacies to expand uptake of ART. We aimed at evaluating the effectiveness of this innovation by comparing the CD4 cell count, weight and viral load of stable HIV patients before and after they were devolved to community pharmacies.

METHODOLOGY

This study was a facility-based retrospective study that analysed the data of HIV patients accessing care at the University of Abuja Teaching Hospital (UATH) Gwagwalada, Abuja, who were devolved to community pharmacies from June 2018 to May 2021. We compared their mean CD4 cell count, weight and viral load before they were devolved and 1 year after devolvement.

RESULTS

A total of 171 patients who met the eligibility criteria were devolved to community pharmacies during the study period. Majority (67.3%) of the patients were females. The age range was 24 years to 72 years with a median age of 42.8 years [inter-quartile range (IQR) 32, 62]. Their mean CD4 cell count (p=0.001) and weight (p=0.006) were higher after devolvement to community pharmacies compared to when they were at the clinic. They all maintained viral suppression after devolvement.

CONCLUSION

ART refill through community pharmacies is effective in maintaining viral suppression in stable HIV patients and may lead to increase in CD4 cell count and weight.

摘要

引言

基于社区的抗逆转录病毒疗法(ART)是一种创新方法,它将艾滋病毒治疗服务提供给更接近人群的地方,消除了前往诊所的后勤障碍,从而提高了抗逆转录病毒疗法的接受率和治疗依从性。美国在尼日利亚的艾滋病紧急救援计划(PEPFAR)项目让社区私营药店参与进来,以扩大抗逆转录病毒疗法的接受率。我们旨在通过比较稳定的艾滋病毒患者转至社区药店前后的CD4细胞计数、体重和病毒载量,来评估这一创新举措的有效性。

方法

本研究是一项基于机构的回顾性研究,分析了2018年6月至2021年5月期间在阿布贾瓜瓜拉达市阿布贾大学教学医院(UATH)接受治疗并转至社区药店的艾滋病毒患者的数据。我们比较了他们在转至社区药店之前和转至社区药店1年后的平均CD4细胞计数、体重和病毒载量。

结果

在研究期间,共有171名符合资格标准的患者转至社区药店。大多数(67.3%)患者为女性。年龄范围为24岁至72岁,中位年龄为42.8岁[四分位间距(IQR)32, 62]。与在诊所时相比,转至社区药店后,他们的平均CD4细胞计数(p = 0.001)和体重(p = 0.006)更高。转至社区药店后,他们都保持了病毒抑制状态。

结论

通过社区药店进行抗逆转录病毒疗法药物补充,对于维持稳定的艾滋病毒患者的病毒抑制有效,并且可能导致CD4细胞计数和体重增加。

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