通过 ATP 水解能量向 ADH1A 酶分子转移，激活酶促乙醇氧化作用，跨越 Müller 细胞中间丝。
Activation of enzymatic ethanol oxidation by ATP hydrolysis energy transferred to ADH1A enzyme molecule over Müller cell intermediate filaments.
机构信息
Faculty of Science and Technology, Department of Chemistry and Pharmacy, and Center of Electronics, Optoelectronics, and Telecommunications, University of the Algarve, Faro, Portugal.
Department of Physics, University of Puerto Rico, Rio Piedras Campus, San Juan, USA.
出版信息
Biophys Chem. 2023 Mar;294:106957. doi: 10.1016/j.bpc.2023.106957. Epub 2023 Jan 13.
Presently exciton activation of enzymatic oxidation of ethanol by human alcohol dehydrogenase (ADH) 1A enzyme is reported. The ADH1A enzyme was activated by infrared (IR) excitons transferred over Müller cell (MC) intermediate filaments (IFs). These IR excitons were generated by energy liberated upon enzymatic ATP hydrolysis and transferred to IFs. Also, the emission spectrum was recorded of the electronically excited ADH1A…NAD…EtOH complexes obtained by energy transfer from IR excitons that traveled along IFs. These results support the hypothesis that ATP hydrolysis energy may be transmitted in vivo in the form of IR excitons, over the network of IFs, both within and between cells.
目前报道了人乙醇脱氢酶（ADH）1A 酶通过激子激活酶促氧化乙醇。ADH1A 酶被通过 Muller 细胞（MC）中间丝（IF）传递的红外（IR）激子激活。这些 IR 激子是由酶促 ATP 水解释放的能量产生的，并转移到 IF 上。此外，还记录了通过沿 IF 传播的 IR 激子进行能量转移获得的电子激发的 ADH1A…NAD…EtOH 配合物的发射光谱。这些结果支持了这样的假设，即 ATP 水解能量可能以 IR 激子的形式在体内传递，通过 IF 网络，在细胞内和细胞之间传递。
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