亮抑酶肽对凝血酶诱导的血小板聚集、纤维蛋白形成及酰胺水解的影响。 - Suppr | 超能文献

Effect of leupeptin on platelet aggregation, fibrin formation and amidolysis induced by thrombin.

作者信息

Ruda E M, Scrutton M C

机构信息

Department of Biochemistry, King's College, Strand, London, U.K.

出版信息

Thromb Res. 1987 Sep 1;47(5):611-9. doi: 10.1016/0049-3848(87)90366-5.

DOI:10.1016/0049-3848(87)90366-5

Abstract

摘要

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1

Effect of leupeptin on platelet aggregation, fibrin formation and amidolysis induced by thrombin.亮抑酶肽对凝血酶诱导的血小板聚集、纤维蛋白形成及酰胺水解的影响。

Thromb Res. 1987 Sep 1;47(5):611-9. doi: 10.1016/0049-3848(87)90366-5.

2

Influence of a calcium dependent protease inhibitor on platelet activation and secretion.一种钙依赖性蛋白酶抑制剂对血小板激活和分泌的影响。

Thromb Res. 1987 Sep 15;47(6):625-37. doi: 10.1016/0049-3848(87)90101-0.

3

Protease and cyclooxygenase inhibitors synergistically prevent activation of human platelets.蛋白酶抑制剂与环氧化酶抑制剂协同作用可防止人血小板激活。

Proc Natl Acad Sci U S A. 1986 May;83(10):3456-9. doi: 10.1073/pnas.83.10.3456.

4

Leupeptin selectively inhibits human platelet responses induced by thrombin and trypsin; a role for proteolytic activation of phospholipase C.亮抑蛋白酶肽选择性抑制凝血酶和胰蛋白酶诱导的人血小板反应；磷脂酶C蛋白水解激活的作用。

Biochem Biophys Res Commun. 1985 Sep 30;131(3):1198-205. doi: 10.1016/0006-291x(85)90218-9.

5

Inhibition of thrombin-induced platelet activation by leupeptin. Implications for the participation of calpain in the initiation of platelet activation.亮抑蛋白酶肽对凝血酶诱导的血小板活化的抑制作用。钙蛋白酶在血小板活化起始过程中的参与情况探讨。

J Biol Chem. 1988 Apr 15;263(11):5210-6.

6

Antipain or leupeptin in combination with aspirin or indomethacin synergistically inhibit human platelet activation by thrombin and trypsin.安替派林或亮抑蛋白酶肽与阿司匹林或吲哚美辛联合使用时，可协同抑制凝血酶和胰蛋白酶对人血小板的激活作用。

Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:563-8.

7

Thrombin-induced platelet aggregation involves an indirect proteolytic cleavage of aggregin by calpain.凝血酶诱导的血小板聚集涉及钙蛋白酶对聚集蛋白的间接蛋白水解切割。

Arch Biochem Biophys. 1989 Jun;271(2):346-58. doi: 10.1016/0003-9861(89)90284-1.

8

Thrombin receptor-activating peptide releases arachidonic acid from human platelets: a comparison with thrombin and trypsin.凝血酶受体激活肽从人血小板中释放花生四烯酸：与凝血酶和胰蛋白酶的比较。

J Pharmacol Exp Ther. 1997 May;281(2):861-7.

9

Leupeptin does not affect the normal signal transduction mechanism in platelets.亮抑酶肽不影响血小板中的正常信号转导机制。

FEBS Lett. 1989 Feb 27;244(2):407-10. doi: 10.1016/0014-5793(89)80573-3.

10

Sustained proteolysis is required for human platelet activation by thrombin.凝血酶激活人血小板需要持续的蛋白水解作用。

Thromb Res. 1986 Apr 15;42(2):247-55. doi: 10.1016/0049-3848(86)90300-2.

引用本文的文献

1

Calpain I activation is not correlated with aggregation in human platelets.钙蛋白酶I的激活与人类血小板的聚集不相关。

Biochem J. 1989 Aug 1;261(3):1039-42. doi: 10.1042/bj2611039.