铸造工人血浆脂联素水平升高与更高的累积粉尘暴露及气道阻塞相关。

An Increase in Plasma Adipsin Levels Is Associated With Higher Cumulative Dust Exposure and Airway Obstruction in Foundry Workers.

作者信息

Koskela Kirsi, Sauni Riitta, Uitti Jukka, Oksa Panu, Moilanen Eeva, Hämäläinen Mari, Lehtimäki Lauri

机构信息

From the Finnish Institute of Occupational Health (Dr Koskela, Dr Oksa); The Outpatient Clinic of Occupational Medicine, Tampere University Hospital, Tampere, Finland (Dr Koskela); Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland (Dr Koskela, Dr Sauni, Dr Uitti, Dr Lehtimäki); The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University, and Tampere University Hospital, Tampere, Finland (Dr Moilanen, Dr Hämäläinen); and Allergy Centre, Tampere University Hospital, Tampere, Finland (Dr Lehtimäki).

出版信息

J Occup Environ Med. 2023 Mar 1;65(3):203-209. doi: 10.1097/JOM.0000000000002736. Epub 2022 Oct 21.

DOI:10.1097/JOM.0000000000002736

PMID:36730948

Abstract

OBJECTIVE

The aim of the study was to assess whether plasma adipokine levels (adipsin, adiponectin, leptin, and resistin) are associated with pulmonary function in foundry workers.

METHODS

We examined 65 dust-exposed foundry workers and 40 nonexposed controls and analyzed their lung function and plasma adipokine levels at baseline and after approximately 7 years of follow-up.

RESULTS

A higher increase in plasma adipsin was associated with the development of airway obstruction in exposed subjects during follow-up after adjusting for body mass index changes during the follow-up period. Furthermore, the increase in adipsin levels was positively associated with cumulative dust exposure even after adjusting for smoking and body mass index changes during follow-up ( P = 0.015).

CONCLUSION

The results suggest that plasma adipsin is involved in the pathogenesis of subclinical airway inflammation and the development of chronic obstruction and is induced by occupational dust exposure.

摘要