基于表面的形态计量学研究一氧化碳中毒患者的大脑。

Surface-based morphometry study of brain in patients with carbon monoxide poisoning.

机构信息

Deparment of Radiology, The First Hospital of Lanzhou University. The Intelligent Imaging Medical Engineering Research Center of Gansu Province, Accurate Image Collaborative Innovation International Science and Technology Cooperation Base of Gansu Province, Radiological Clinical Medicine Research Center of Gansu Province, Lanzhou, Gansu, China; Department of Neurology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.

出版信息

Eur J Radiol. 2023 Mar;160:110711. doi: 10.1016/j.ejrad.2023.110711. Epub 2023 Jan 28.

DOI:10.1016/j.ejrad.2023.110711

PMID:36731402

Abstract

PURPOSE

Although cortical volume abnormalities are frequently detected in patients with carbon monoxide poisoning (COP), particularly delayed neurological sequelae (DNS), the associated changes in cortical thickness and shape patterns remain unknown.

MATERIALS & METHODS: Using surface-based morphometry, we investigated the differences in cortical thickness and shape indices between a COP group (n = 44) vs healthy controls (HCs, n = 36), and between the DNS (n = 21) vs non-DNS (n = 23) subgroups. Additionally, the influence of cortical damage on neurological disorders was explored.

RESULTS

The COP group exhibited significant cortical thinning mainly in the bilateral fronto-parietal lobes (P < 0.05, family-wise error corrected). When cortical thinning in the bilateral parietal lobes, bilateral primary motor areas, left primary sensory areas, and bilateral paracentral lobules was explored in the DNS subgroups compared to the non-DNS subgroup (P < 0.05, FWE corrected), no differences in shape indices between the two subgroups were noted. In the COP group, there were significant positive correlations between the Mini-Mental State Examination (MMSE) score and cortical thickness in the right superior frontal gyrus (SFG) and bilateral rostral middle frontal gyrus (rMFG) (P < 0.05, false discovery rate corrected). There was no any significant correlation between cortical thickness and Neuropsychiatric inventory (NPI), UPDRS III scores (P > 0.05, FDR-corrected).

CONCLUSION

Cortical thickness is a more sensitive index than shape for measuring cortical damage in patients with COP exposure, as cortical thinning in the right SFG and bilateral rMFG is related to cognitive impairment.

摘要

目的

尽管一氧化碳中毒（COP）患者经常出现皮质体积异常，尤其是迟发性神经后遗症（DNS），但皮质厚度和形状模式的相关变化尚不清楚。

材料与方法

使用基于表面的形态计量学，我们研究了 COP 组（n=44）与健康对照组（HCs，n=36）之间皮质厚度和形状指数的差异，以及 DNS 组（n=21）与非-DNS 组（n=23）之间的差异。此外，还探讨了皮质损伤对神经障碍的影响。

结果

COP 组表现出双侧额顶叶皮质变薄（P<0.05，校正后的全脑错误率）。当 DNS 亚组与非-DNS 亚组相比，在双侧顶叶、双侧初级运动区、左侧初级感觉区和双侧旁中央小叶中发现皮质变薄时（P<0.05，校正后的全脑错误率），两个亚组之间的形状指数没有差异。在 COP 组中，简易精神状态检查表（MMSE）评分与右侧额上回（SFG）和双侧额中回前部（rMFG）皮质厚度之间存在显著正相关（P<0.05，经错误发现率校正）。皮质厚度与神经精神问卷（NPI）、UPDRS III 评分之间无显著相关性（P>0.05，经 FDR 校正）。