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对哮喘持续状态患儿进行双水平气道正压通气时的肠内营养。

Enteral Feeding for Children on Bilevel Positive Pressure Ventilation for Status Asthmaticus.

作者信息

Komeswaran Kavipriya, Khanal Aayush, Powell Kimberly, Caprirolo Giovanna, Majcina Ryan, Robbs Randall S, Basnet Sangita

机构信息

Department of Pediatrics, Southern Illinois University School of Medicine, Springfield, Illinois, United Sates.

Center for Clinical Research, Southern Illinois University School of Medicine, Springfield, Illinois, United Sates.

出版信息

J Pediatr Intensive Care. 2021 Jun 8;12(1):31-36. doi: 10.1055/s-0041-1730901. eCollection 2023 Mar.

Abstract

A retrospective data analysis was conducted to evaluate enteral nutrition practices for children admitted with status asthmaticus in a single-center pediatric intensive care unit. Of 406 charts, 315 were analyzed (63% male); 135 on bilevel positive airway pressure ventilation (BIPAP) and 180 on simple mask. Overall median age and weight were 6.0 (interquartile range [IQR]: 6.0) years and 24.8 (IQR: 20.8) kg, respectively. All children studied were on full feeds while still on BIPAP and simple mask; 99.3 and 100% were fed per oral, respectively. Median time to initiation of feeds and full feeds was longer in the BIPAP group, 11.0 (IQR: 20) and 23.0 hours (IQR: 26), versus simple mask group, 4.3 (IQR: 7) and 12.0 hours (IQR: 15),  = 0.001. The results remained similar after adjusting for gender, weight, clinical asthma score at admission, use of adjunct therapy, and duration of continuous albuterol. By 24 hours, 81.5% of patients on BIPAP and 96.6% on simple mask were started on feeds. Compared with simple mask, patients on BIPAP were sicker with median asthma score at admission of 4 (IQR: 2) versus 3 (IQR: 2) on simple mask, requiring more adjunct therapy (80.0 vs. 43.9%), and a longer median length of therapy of 41.0 (IQR: 41) versus 20.0 hours (IQR: 29), respectively,  = 0.001. There were no complications such as aspiration pneumonia, and none required invasive mechanical ventilation in either group. Enteral nutrition was effectively and safely initiated and continued for children admitted with status asthmaticus, including those on noninvasive bilevel ventilation therapy.

摘要

进行了一项回顾性数据分析,以评估在一家单中心儿科重症监护病房中,因哮喘持续状态入院的儿童的肠内营养实践情况。在406份病历中,分析了315份(男性占63%);其中135例采用双水平气道正压通气(BIPAP),180例采用简易面罩。总体中位年龄和体重分别为6.0岁(四分位间距[IQR]:6.0)和24.8千克(IQR:20.8)。所有研究对象在使用BIPAP和简易面罩时均接受全量喂养;经口喂养的比例分别为99.3%和100%。BIPAP组开始喂养和达到全量喂养的中位时间较长,分别为11.0小时(IQR:20)和23.0小时(IQR:26),而简易面罩组分别为4.3小时(IQR:7)和12.0小时(IQR:15),P = 0.001。在对性别、体重、入院时的临床哮喘评分、辅助治疗的使用情况以及持续使用沙丁胺醇的时间进行校正后,结果仍然相似。到24小时时,使用BIPAP的患者中有81.5%开始喂养,使用简易面罩的患者中有96.6%开始喂养。与简易面罩组相比,使用BIPAP的患者病情更重,入院时哮喘中位评分为4分(IQR:2),而简易面罩组为3分(IQR:2),需要更多辅助治疗(80.0%对43.9%),中位治疗时间更长,分别为41.0小时(IQR:41)和20.0小时(IQR:29),P = 0.001。两组均未发生诸如吸入性肺炎等并发症,也均无患者需要有创机械通气。对于因哮喘持续状态入院的儿童,包括接受无创双水平通气治疗的儿童,肠内营养能够有效且安全地开始并持续进行。

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本文引用的文献

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Non-invasive positive pressure ventilation for acute asthma in children.儿童急性哮喘的无创正压通气
Cochrane Database Syst Rev. 2016 Sep 30;9(9):CD012067. doi: 10.1002/14651858.CD012067.pub2.

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