Section for Pediatric Endocrinology, Cleveland Clinic Children's, 9500 Euclid Avenue, R Building- R-3, Cleveland, OH 44195, USA.
University Hospitals Cleveland Medical Center, Rainbow Babies and Children's Hospital, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
Endocrinol Metab Clin North Am. 2023 Mar;52(1):175-185. doi: 10.1016/j.ecl.2022.08.001. Epub 2022 Nov 18.
Type 1 diabetes is a chronic autoimmune disorder that results in destruction of insulin-producing cells in the pancreas. The autoimmune process is thought to be waxing and waning resulting in variable endogenous insulin secretion ability. An example of this is the honeymoon phase or partial remission phase of type 1 diabetes, during which optimal control of blood glucoses can be maintained with significantly reduced exogenous insulin, and occasionally exogenous insulin can be temporarily discontinued altogether. Understanding this phase is important because even fairly small amounts of endogenous insulin secretion is associated with reduced risk of severe hypoglycemia and microvascular complications.
1 型糖尿病是一种慢性自身免疫性疾病，导致胰腺中产生胰岛素的细胞被破坏。自身免疫过程被认为是时强时弱的，导致内源性胰岛素分泌能力的变化。这种情况的一个例子是 1 型糖尿病的蜜月期或部分缓解期，在此期间，可以用明显减少的外源性胰岛素来维持血糖的最佳控制，有时甚至可以完全暂时停止外源性胰岛素。了解这一阶段很重要，因为即使是相当少量的内源性胰岛素分泌也与严重低血糖和微血管并发症风险的降低有关。
