Alvarado Francisco, Kaban Jody, Chao Edward, Meltzer James A
Jacobi Medical Center, Department of Surgery, 1400 Pelham Parkway South, Bronx, NY 10461, United States of America.
Jacobi Medical Center, Department of Surgery, Division of Trauma, 1400 Pelham Parkway South, Bronx, NY 10461, United States of America.
Injury. 2023 May;54(5):1287-1291. doi: 10.1016/j.injury.2023.02.009. Epub 2023 Feb 6.
Prior studies have shown that the surgical stabilization of rib fractures (SSRF) for patients with multiple rib fractures is associated with improved outcomes by restoring chest wall integrity and decreasing time to return to prior functional status. It is unclear if patients with pulmonary comorbidities (PCM) would benefit from this procedure.
To compare the difference in morbidity and mortality of patients with multiple rib fractures undergoing SSRF who have underlying PCM to those who do not have PCM.
We performed a retrospective cohort study of patients with multiple rib fractures using data from the Trauma Quality Improvement Program (January 2015 to December 2018). Patients with penetrating injuries, those who died within the first 24 h, those with substantial head, spine, or abdominopelvic injuries, and those who were pregnant, were excluded. A PCM was defined as chronic lower respiratory disease, active smoking, or morbid obesity. Dichotomous outcomes were adjusted for potential confounders by creating a propensity score for PCM and applying inverse probability weighting. The propensity score accounted for multiple patient-level and hospital level covariates. Continuous outcomes were adjusted for these same covariates using multivariable quantile regression.
Of the 4,084 patients who underwent SSRF, 3048 (75%) were males, the median age was 57 years [IQR 47, 66], and 1504 (37%) had at least one PCM. After adjusting for the propensity score, patients with PCM who underwent SSRF had no significant difference in mortality compared to those without PCM (absolute difference, 0.7% [95% CI -0.2, 1.7]). Similarly, there was no significant difference in time on the ventilator (0.6 days [-0.1, 1.4]). Patients with PCM, however, had a statistically significantly longer hospital LOS (0.8 days [0.3, 1.3]) and ICU LOS (0.6 days [0.1, 1.1]), higher risk of tracheostomy (2.7% [0.1, 4.6]) and higher probability of pulmonary complications (2.7% [1.2, 4.2]), compared to those without PCM.
Among patients with multiple rib fractures who undergo SSRF, having a PCM did not result in a clinically important higher probability of dying or experiencing substantial morbidity. This factor should not exclude patients with PCM from receiving SSRF for multiple rib fractures but the small increased risk in morbidity should be discussed with patients prior to SSRF.
先前的研究表明,对于多根肋骨骨折患者,手术固定肋骨骨折(SSRF)通过恢复胸壁完整性和缩短恢复至先前功能状态的时间,可改善预后。尚不清楚患有肺部合并症(PCM)的患者是否能从该手术中获益。
比较接受SSRF的多根肋骨骨折且患有潜在PCM的患者与未患有PCM的患者在发病率和死亡率上的差异。
我们使用创伤质量改进计划(2015年1月至2018年12月)的数据,对多根肋骨骨折患者进行了一项回顾性队列研究。排除穿透伤患者、伤后24小时内死亡的患者、有严重头部、脊柱或腹部盆腔损伤的患者以及孕妇。PCM定义为慢性下呼吸道疾病、当前吸烟或病态肥胖。通过为PCM创建倾向评分并应用逆概率加权,对二分结局调整潜在混杂因素。倾向评分考虑了多个患者层面和医院层面的协变量。使用多变量分位数回归对这些相同的协变量调整连续结局。
在4084例接受SSRF的患者中,3048例(75%)为男性,中位年龄为57岁[四分位间距47, 66],1504例(37%)至少有一种PCM。在调整倾向评分后,接受SSRF的患有PCM的患者与未患有PCM的患者相比,死亡率无显著差异(绝对差异,0.7%[95%置信区间 -0.2, 1.7])。同样,呼吸机使用时间无显著差异(0.6天[-0.1, 1.4])。然而与未患有PCM的患者相比,患有PCM的患者住院时间在统计学上显著更长(0.8天[0.3, 1.3]),重症监护病房(ICU)住院时间更长(0.6天[0.1, 1.1]),气管切开风险更高(2.7%[0.1, 4.6]),肺部并发症发生概率更高(2.7%[1.2, 4.2])。
在接受SSRF的多根肋骨骨折患者中,患有PCM并不会导致临床上更高的死亡概率或显著更高的发病率。该因素不应排除患有PCM的患者接受多根肋骨骨折的SSRF治疗,但在进行SSRF之前,应与患者讨论发病率略有增加的风险。