Department of Pediatrics, Lady Hardinge Medical College and associated Kalawati Saran Children's Hospital, New Delhi, India.
Department of Internal Medicine, VMMC and Safdarjung Hospital, New Delhi, India.
Indian J Pediatr. 2023 Dec;90(12):1177-1181. doi: 10.1007/s12098-022-04414-7. Epub 2023 Feb 10.
To study the serum calprotectin levels in children with juvenile idiopathic arthritis (JIA) and correlate it with C-reactive protein (CRP) and the Juvenile Arthritis Disease Activity Score-27 (JADAS-27).
This was a cross-sectional observational study done between November 2017 and March 2019. Fifty treatment-naive children, aged 1 to 18 y with the diagnosis of JIA as per the International League of Associations of Rheumatology (ILAR) criteria were enrolled. Assessment of disease activity was done according to the Juvenile Arthritis Disease Activity Score (JADAS-27). Determination of serum calprotectin and CRP levels was done by immunoassay. The correlation between calprotectin levels with CRP and JADAS-27 was calculated.
Of the 50 patients with JIA included in the study, there were 18 female and 32 male children. The median age of presentation to the hospital was 9 y (IQR 5.82-13). The median JADAS-27 was 14 (IQR 6, 20.25). The median serum calprotectin level was 45,375 ng/mL (IQR 30,725, 52,270; range 8,560-63,160 ng/mL). The median CRP was 35.4 mg/L (IQR 3.48, 80.3; range 0.02 and 107.4 mg/L). The levels of calprotectin in different JIA subtypes were not statistically different using Kruskal-Wallis test. The study also demonstrated a positive correlation between serum calprotectin with CRP and the JADAS-27 (r = 0.418).
The calprotectin levels in JIA were significantly higher than those reported in the literature irrespective of the subtype. Serum calprotectin positively correlated with CRP and JADAS-27 in children with JIA.
研究儿童幼年特发性关节炎（JIA）患者的血清钙卫蛋白水平，并与 C 反应蛋白（CRP）和 27 项青少年关节炎疾病活动评分（JADAS-27）进行相关性分析。
这是一项 2017 年 11 月至 2019 年 3 月期间进行的横断面观察性研究。共纳入 50 例初治的 JIA 患儿（根据国际风湿病联盟（ILAR）标准诊断），年龄 1 至 18 岁。根据青少年关节炎疾病活动评分（JADAS-27）评估疾病活动度。通过免疫测定法测定血清钙卫蛋白和 CRP 水平。计算钙卫蛋白水平与 CRP 和 JADAS-27 的相关性。
在纳入研究的 50 例 JIA 患儿中，女性 18 例，男性 32 例。就诊时的中位年龄为 9 岁（IQR 5.82-13）。中位 JADAS-27 为 14（IQR 6，20.25）。中位血清钙卫蛋白水平为 45375ng/ml（IQR 30725，52270；范围 8560-63160ng/ml）。中位 CRP 为 35.4mg/L（IQR 3.48，80.3；范围 0.02-107.4mg/L）。不同 JIA 亚型的钙卫蛋白水平在 Kruskal-Wallis 检验中无统计学差异。研究还表明，血清钙卫蛋白与 CRP 和 JADAS-27 呈正相关（r=0.418）。
JIA 患儿的钙卫蛋白水平明显高于文献报道的水平，且与亚型无关。血清钙卫蛋白与 CRP 和 JADAS-27 在 JIA 患儿中呈正相关。
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