Chekulaev V A, Shelepov V P, Pasha-zade G R, Shapot V S
Biokhimiia. 1987 Sep;52(9):1501-11.
In order to elucidate the peculiarities of brain metabolism in tumour-bearing organisms, the arterio-venous (A-V) content of glucose, acetoacetate (Ac-Ac), beta-hydroxybutyrate (beta-HB) and non-esterified fatty acids (NEFA) in growing Zajdela ascite hepatoma (ZAH) and solid hepatoma 27 (H-27) was compared. Analysis of metabolic patterns of healthy, starving and fed recipients (ZAH and H-27) revealed the inadequacy of the concepts on anorexia as being the cause of carbohydrate-lipid metabolic disturbances. In tumour-bearing organisms lipolysis and ketogenesis reflect the tumour-induced chronic stress. Absorption of beta-HB and release of Ac-Ac by brain were observed at all stages of malignant growth. This is probably due to a partial switch-over of brain metabolism to non-carbohydrate energy sources. Besides, certain stages of tumour growth are associated with active assimilation of NEFA by brain. A correlation between the A-V difference with respect to glucose and Ac-Ac as well as between the glucose and NEFA contents was established. It was assumed that the A-V difference in glucose is the main regulator of ketone body metabolism.
为了阐明荷瘤生物体脑代谢的特点，比较了生长中的扎伊德拉腹水肝癌（ZAH）和实体肝癌27（H-27）中葡萄糖、乙酰乙酸（Ac-Ac）、β-羟基丁酸（β-HB）和非酯化脂肪酸（NEFA）的动静脉（A-V）含量。对健康、饥饿和喂食的受体（ZAH和H-27）的代谢模式分析表明，将厌食症视为碳水化合物-脂质代谢紊乱原因的观点并不充分。在荷瘤生物体中，脂肪分解和生酮作用反映了肿瘤诱导的慢性应激。在恶性生长的各个阶段均观察到脑对β-HB的吸收和Ac-Ac的释放。这可能是由于脑代谢部分转向非碳水化合物能量来源。此外，肿瘤生长的某些阶段与脑对NEFA的活跃同化有关。建立了葡萄糖和Ac-Ac的A-V差异之间以及葡萄糖和NEFA含量之间的相关性。假定葡萄糖的A-V差异是酮体代谢的主要调节因子。
