Laboratory of Asymmetric Synthesis, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing 402160, P. R. China.
J Org Chem. 2023 Mar 3;88(5):2822-2831. doi: 10.1021/acs.joc.2c02484. Epub 2023 Feb 10.
A mild bromination of pyrrolo[2,1-]isoquinolines has been achieved using acetyl bromide and dimethyl sulfoxide. A series of brominated pyrrolo[2,1-]isoquinolines could be obtained in moderate to excellent yields (46-99%) at room temperature. This strategy can also be expanded to the facile bromination of polysubstituted pyrroles, indoles, electron-rich phenols, aniline, and 2-naphthol.
采用乙酰溴和二甲亚砜实现了吡咯并[2,1-α]异喹啉的温和溴化反应。在室温下，一系列溴化吡咯并[2,1-α]异喹啉可以以中等至优秀的收率（46-99%）获得。该策略还可以扩展到多取代吡咯、吲哚、富电子苯酚、苯胺和 2-萘酚的简便溴化。
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