Siegal G P, Oliver W R, Reinus W R, Gilula L A, Foulkes M A, Kissane J M, Askin F B
Department of Pathology, University of North Carolina, Chapel Hill 27599.
Cancer. 1987 Dec 1;60(11):2829-40. doi: 10.1002/1097-0142(19871201)60:11<2829::aid-cncr2820601139>3.0.co;2-s.
Ewing's sarcoma is a rare tumor of the bone. In the Intergroup Ewing's Sarcoma Study (IESS) approximately 4% of the primary bone tumors arose in the bones of the head and neck. The mean age of patients was 10.9 years; boys slightly dominated the group. Signs and symptoms were local in distribution, with a mass or swelling most frequent. As in other sites, we categorized the dominant histologic pattern as diffuse or filigree, the latter carrying a more unfavorable prognosis. The radiographic appearance may be atypical as compared to Ewing's sarcoma at other sites. Prognosis of head and neck Ewing's is significantly better than Ewing's sarcoma overall. The gnathic bones were commonly affected, yet there was no associated mortality. No patient with primary disease in the bones of the head and neck who survived for 5 years on any of the IESS protocols has subsequently died.
尤因肉瘤是一种罕见的骨肿瘤。在尤因肉瘤协作组研究（IESS）中，约4%的原发性骨肿瘤发生于头颈部骨骼。患者的平均年龄为10.9岁；该组中男孩略占多数。体征和症状呈局部分布，最常见的是肿块或肿胀。与其他部位一样，我们将主要组织学模式分为弥漫型或细丝型，后者预后更差。与其他部位的尤因肉瘤相比，其影像学表现可能不典型。头颈部尤因肉瘤的预后总体上明显优于尤因肉瘤。颌骨常受累，但无相关死亡病例。在任何IESS方案中存活5年的头颈部原发性疾病患者均未随后死亡。
