Tu Samuel J, Wong Christopher X, Stokes Michael B, Pitman Bradley M, Sanders Prashanthan, Lau Dennis H
Centre for Heart Rhythm Disorders, The University of Adelaide, Adelaide, Australia.
Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia.
J Cardiol Cases. 2022 Nov 10;27(2):80-83. doi: 10.1016/j.jccase.2022.10.011. eCollection 2023 Feb.
Although cardiac resynchronization therapy (CRT) is an established therapy in selected patients with heart failure with reduced ejection fraction (HFrEF), its role in orthotopic heart transplant (OHT) recipients remains understudied. We describe a case of successful CRT implantation in an OHT recipient for HFrEF and high-grade atrioventricular block. This case highlights the deliberations made given the lack of clinical trial and observational evidence for this therapy in OHT recipients.
This case demonstrates the feasibility of cardiac resynchronization therapy (CRT) in an orthotopic heart transplant (OHT) recipient and adds to the scarcely reported data on the utility of CRT in this population. Given the exclusion of OHT recipients from the major CRT trials, further research is required to refine the indications for CRT implantation in this population.
尽管心脏再同步治疗(CRT)在部分射血分数降低的心力衰竭(HFrEF)患者中是一种既定的治疗方法,但其在原位心脏移植(OHT)受者中的作用仍未得到充分研究。我们描述了一例成功为一名HFrEF和高度房室传导阻滞的OHT受者植入CRT的病例。该病例凸显了鉴于缺乏针对OHT受者的该治疗方法的临床试验和观察性证据而进行的考量。
本病例证明了心脏再同步治疗(CRT)在原位心脏移植(OHT)受者中的可行性,并补充了关于CRT在该人群中效用的极少报道的数据。鉴于主要的CRT试验排除了OHT受者,需要进一步研究以完善该人群中CRT植入的适应症。