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应用 QuantiFERON-TB Gold Plus 试剂盒检测潜伏性结核感染在监狱工作人员中的应用:巴西弗朗西斯科·贝尔特朗市的一项横断面研究。

Latent Tuberculosis Infection Diagnosis Using QuantiFERON-TB Gold Plus Kit Among Correctional Workers: A Cross-Sectional Study in Francisco Beltrão-PR, Brazil.

机构信息

Health Sciences Center, Postgraduate Program in Applied Health Sciences, Western Paraná State University (UNIOESTE), Francisco Beltrão, Brazil.

Health Sciences Center, Faculty of Medicine, Public Health Lab and Biosciences and Health Lab, Western Paraná State University (UNIOESTE), Francisco Beltrão, Brazil.

出版信息

J Community Health. 2023 Aug;48(4):600-605. doi: 10.1007/s10900-023-01201-z. Epub 2023 Feb 16.

Abstract

Correctional workers form a high-priority group for tuberculosis control measures because of their high exposure and risk. This cross-sectional study conducted in April and May 2022 included 71 criminal police officers from the State Penitentiary of Francisco Beltrão-PR, Brazil. Their sociodemographic and laboratory data were collected. Latent tuberculosis infection (LTBI) was assessed using a QuantiFERON-TB Gold Plus in-tube test kit. Binary logistic regression was applied to calculate the odds ratios (ORs) and 95% confidence intervals (CI) of the LTBI predictors. The prevalence of LTBI was 22.6% (95% CI, 12.8-32.2%). Factors associated with LTBI were age > 43 years (OR, 0.18; 95% CI, 0.04-0.70; p < 0.014) and the use of medications (OR, 5.13; 95% CI, 1.40-18.87; p < 0.014). The prevalence was close to that estimated worldwide for LTBI in correctional workers, reinforcing the need for occupational health control measures consisting of regular screening and treatment of positive cases of latent infection among correctional workers to reduce the risk of illness and spread of infection in the penitentiary system and community.

摘要

惩教工作人员由于接触和感染风险较高,成为结核病控制措施的重点高优先级群体。这项横断面研究于 2022 年 4 月至 5 月在巴西弗朗西斯科·贝尔特朗州立监狱进行,共纳入 71 名刑事警察。收集了他们的社会人口学和实验室数据。使用 QuantiFERON-TB Gold Plus 管内检测试剂盒评估潜伏性结核感染 (LTBI)。应用二项逻辑回归计算 LTBI 预测因素的比值比 (OR) 和 95%置信区间 (CI)。LTBI 的患病率为 22.6% (95%CI,12.8-32.2%)。与 LTBI 相关的因素是年龄>43 岁 (OR,0.18;95%CI,0.04-0.70;p<0.014) 和使用药物 (OR,5.13;95%CI,1.40-18.87;p<0.014)。该患病率接近全球惩教工作者 LTBI 的估计患病率,这加强了需要采取职业健康控制措施,包括对惩教工作者中的潜伏感染阳性病例进行定期筛查和治疗,以降低在监狱系统和社区中患病和感染传播的风险。

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