内耳 T1 钆后信号强度增加与散发前庭神经鞘瘤患者同侧感音神经性听力损失程度相关。
Increased Labyrinthine T1 Postgadolinium Signal Intensity Is Associated with the Degree of Ipsilateral Sensorineural Hearing Loss in Patients with Sporadic Vestibular Schwannoma.
机构信息
From the Departments of Radiology (J.P.W., J.C.B., J.I.L.)
From the Departments of Radiology (J.P.W., J.C.B., J.I.L.).
出版信息
AJNR Am J Neuroradiol. 2023 Mar;44(3):317-322. doi: 10.3174/ajnr.A7800. Epub 2023 Feb 16.
BACKGROUND AND PURPOSE
Vestibular schwannomas are benign, generally slow-growing tumors, commonly presenting with hearing loss. Alterations in the labyrinthine signal are seen in patients with vestibular schwannoma; however, the association between imaging abnormalities and hearing function remains poorly defined. The purpose of this study was to determine whether labyrinthine signal intensity is associated with hearing in patients with sporadic vestibular schwannoma.
MATERIALS AND METHODS
This was an institutional review board-approved retrospective review of patients from a prospectively maintained vestibular schwannoma registry imaged in 2003-2017. Signal-intensity ratios of the ipsilateral labyrinth were obtained using T1, T2-FLAIR, and postgadolinium T1 sequences. Signal-intensity ratios were compared with tumor volume and audiometric hearing threshold data including pure tone average, word recognition score, and American Academy of Otolaryngology-Head and Neck Surgery hearing class.
RESULTS
One hundred ninety-five patients were analyzed. Ipsilateral labyrinthine signal intensity including postgadolinium T1 images was positively correlated with tumor volume (correlation coefficient = 0.17, = .02). Among signal-intensity ratios, postgadolinium T1 was significantly positively associated with pure tone average (correlation coefficient = 0.28, < .001) and negatively associated with the word recognition score (correlation coefficient = -0.21, = .003). Overall, this result correlated with impaired American Academy of Otolaryngology-Head and Neck Surgery hearing class ( = .04). Multivariable analysis suggested persistent associations independent of tumor volume with pure tone average (correlation coefficient = 0.25, < .001) and the word recognition score (correlation coefficient = -0.17, = .02) but not hearing class ( = .14). No consistent significant associations were noted between noncontrast T1 and T2-FLAIR signal intensities and audiometric testing.
CONCLUSIONS
Increased ipsilateral labyrinthine postgadolinium signal intensity is associated with hearing loss in patients with vestibular schwannoma.
背景与目的
前庭神经鞘瘤是良性的、生长缓慢的肿瘤，通常表现为听力损失。前庭神经鞘瘤患者的迷路信号会发生改变；然而，影像学异常与听力功能之间的关系仍未得到明确界定。本研究旨在确定单侧前庭神经鞘瘤患者的迷路信号强度是否与听力相关。
材料与方法
这是一项经过机构审查委员会批准的回顾性研究，纳入了 2003 年至 2017 年期间在一个前瞻性维持的前庭神经鞘瘤登记处接受成像检查的患者。使用 T1、T2-FLAIR 和钆后 T1 序列获得同侧迷路的信号强度比。信号强度比与肿瘤体积和纯音平均听阈、言语识别得分以及美国耳鼻喉科学会-头颈外科学会听力分级等听力阈值数据进行比较。
结果
共分析了 195 例患者。同侧迷路信号强度（包括钆后 T1 图像）与肿瘤体积呈正相关（相关系数 = 0.17， =.02）。在信号强度比中，钆后 T1 与纯音平均听阈呈显著正相关（相关系数 = 0.28， < .001），与言语识别得分呈负相关（相关系数 = -0.21， =.003）。总的来说，这与美国耳鼻喉科学会-头颈外科学会听力分级较差相关（ =.04）。多变量分析表明，在考虑肿瘤体积的情况下，纯音平均听阈（相关系数 = 0.25， < .001）和言语识别得分（相关系数 = -0.17， =.02）与信号强度比仍存在显著相关性，但与听力分级无关（ =.14）。在非对比 T1 和 T2-FLAIR 信号强度与听力测试之间未发现一致的显著相关性。
结论
单侧前庭神经鞘瘤患者的迷路钆后信号强度增加与听力损失相关。
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