Meijer G W, De Bruijne J J, Beynen A C
Department of Laboratory Animal Science, State University, Utrecht, The Netherlands.
Int J Vitam Nutr Res. 1987;57(3):319-26.
In rats fed semipurified cholesterol-free diets, dietary corn oil induced higher levels of liver cholesterol, but lower concentrations of plasma cholesterol, plasma triglycerides and blood D-3-hydroxybutyric acid, than did coconut fat. Addition of cholesterol to the diets (1%, w/w) greatly increased liver cholesterol levels but did not affect the corn oil effect upon liver and plasma cholesterol. In contrast, dietary cholesterol prevented the corn oil effects upon plasma triglycerides and blood D-3-hydroxybutyric acid. Liver glycogen levels in rats increased significantly after cholesterol feeding, the effect being independent of dietary fat type. In mice, dietary corn oil, compared to coconut fat, elevated liver cholesterol only when the diet contained cholesterol. Corn oil caused an increase of liver glycogen in mice in the presence, but not in the absence of dietary cholesterol. This study shows that dietary cholesterol-fat type combinations influence various aspects of lipid and carbohydrate metabolism in rats and mice.
在喂食半纯化无胆固醇饮食的大鼠中，与椰子油相比，膳食玉米油会使肝脏胆固醇水平升高，但血浆胆固醇、血浆甘油三酯和血液D-3-羟基丁酸的浓度降低。在饮食中添加胆固醇（1%，w/w）可大幅提高肝脏胆固醇水平，但不影响玉米油对肝脏和血浆胆固醇的作用。相比之下，膳食胆固醇可阻止玉米油对血浆甘油三酯和血液D-3-羟基丁酸的作用。喂食胆固醇后，大鼠肝脏糖原水平显著升高，这种作用与膳食脂肪类型无关。在小鼠中，与椰子油相比，只有当饮食中含有胆固醇时，膳食玉米油才会提高肝脏胆固醇水平。在有膳食胆固醇存在但无膳食胆固醇时，玉米油会使小鼠肝脏糖原增加。这项研究表明，膳食胆固醇与脂肪类型的组合会影响大鼠和小鼠脂质和碳水化合物代谢的各个方面。
