College of Health, Wellbeing and Life Sciences, Sheffield Hallam University, Sheffield, England.
College of Health, Wellbeing and Life Sciences, Sheffield Hallam University, Sheffield, England.
J Med Imaging Radiat Sci. 2023 Jun;54(2S):S104-S114. doi: 10.1016/j.jmir.2023.01.007. Epub 2023 Feb 15.
Individuals living with severe mental illness (SMI) have a reduced life expectancy of approximately 15-20 years compared to the general population. Individuals with SMI and comorbid cancer have increased cancer related mortality rates compared to the non SMI population. This scoping review examines the current evidence in relation to the impact on cancer outcomes where individuals have a pre-existing SMI.
Scopus, PsychINFO, PubMed, PsycArticles and the Cochrane Library were searched for peer reviewed research articles, published in English language between 2001 and 2021. Initial title and abstract screening, followed by full text screening sourced articles reporting on the impact of SMI and cancer on: stage at diagnosis, survival, treatment access or quality of life. Articles were quality appraised, and data were extracted and summarised.
The search yielded 1226 articles, 27 met the inclusion criteria. The search yielded no articles that met the inclusion criteria that were from the perspective of the service user or that were focused on the impact of SMI and cancer quality of life. Three themes were developed following analysis: Cancer related mortality, stage at diagnosis, and access to stage appropriate treatment.
The collective study of populations with comorbid SMI and cancer is complex and challenging without a large-scale cohort study. The studies yielded through this scoping review were heterogenous and often study multiple diagnoses of SMI and cancer. Collectively these indicate that cancer related mortality is increased in the population of individuals with pre-existing SMI and the SMI population are more likely to have an increased likelihood of metastatic disease at diagnosis and less likely to receive stage appropriate treatment.
Individuals with pre-existing SMI and cancer have increased cancer specific mortality. Comorbid SMI and cancer is complex, and individuals with SMI and cancer are less likely to receive optimal treatments, experience increased interruptions and delays to treatment.
与普通人群相比，患有严重精神疾病（SMI）的个体预期寿命缩短了约 15-20 年。与非 SMI 人群相比，患有 SMI 和合并癌症的个体癌症相关死亡率更高。本范围综述检查了与个体存在先前 SMI 相关的癌症结果的当前证据。
在 Scopus、PsychINFO、PubMed、PsycArticles 和 Cochrane Library 中搜索了同行评审的研究文章，这些文章发表于 2001 年至 2021 年期间，使用英文撰写。最初筛选标题和摘要，然后筛选全文，筛选出报告 SMI 和癌症对以下方面影响的文章：诊断时的分期、生存、治疗机会或生活质量。对文章进行质量评估，并提取和总结数据。
搜索共产生了 1226 篇文章，其中 27 篇符合纳入标准。搜索结果没有符合纳入标准的文章，这些文章来自服务使用者的角度，或者专注于 SMI 和癌症生活质量的影响。分析后确定了三个主题：癌症相关死亡率、诊断时的分期和获得适合分期的治疗。
没有大规模队列研究，对患有合并 SMI 和癌症的人群进行集体研究是复杂和具有挑战性的。本范围综述中得出的研究结果存在异质性，并且经常研究多种 SMI 和癌症的诊断。总的来说，这些研究表明，患有先前 SMI 的人群中癌症相关死亡率增加，并且 SMI 人群更有可能在诊断时患有转移性疾病，并且更不可能接受适合分期的治疗。
患有先前 SMI 和癌症的个体癌症特异性死亡率增加。合并 SMI 和癌症是复杂的，患有 SMI 和癌症的个体更不可能接受最佳治疗，治疗中断和延迟的情况增加。
