肽基tRNA的积累对大肠杆菌是致命的。
Accumulation of peptidyl tRNA is lethal to Escherichia coli.
作者信息
Menninger J R
出版信息
J Bacteriol. 1979 Jan;137(1):694-6. doi: 10.1128/jb.137.1.694-696.1979.
Abstract
A mutant strain of Escherichia coli with temperature-sensitive peptidyl-tRNA hydrolase grows at 30 degrees C but, when shifted to 40 degrees C, dies at rates affected by physiological, pharmacological, and genetical perturbations. The rate of killing correlates with the relative accumulation of peptidyl-tRNA, suggesting that it is responsible for the death of the cells.
摘要
一种具有温度敏感性肽基 - tRNA水解酶的大肠杆菌突变株在30摄氏度时生长，但当转移到40摄氏度时，会因生理、药理和遗传扰动而以不同速率死亡。细胞死亡速率与肽基 - tRNA的相对积累相关，这表明肽基 - tRNA的积累是细胞死亡的原因。
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本文引用的文献
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Studies on the metabolic role of peptidyl-tRNA hydrolase. I. Properties of a mutant E. coli with temperature-sensitive peptidyl-tRNA hydrolase.肽基 - tRNA水解酶代谢作用的研究。I. 具有温度敏感性肽基 - tRNA水解酶的大肠杆菌突变体的特性。
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Mutant E. coli strain with temperature sensitive peptidyl-transfer RNA hydrolase.具有温度敏感性肽基转移RNA水解酶的突变大肠杆菌菌株。
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Release of (oligo) peptidyl-tRNA from ribosomes by erythromycin A.红霉素A促使（寡）肽基-tRNA从核糖体上释放
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Peptidyl transfer RNA dissociates during protein synthesis from ribosomes of Escherichia coli.肽基转移RNA在蛋白质合成过程中从大肠杆菌核糖体上解离。
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