即兴加花段:cGAS 和 STING 在 Ca2+依赖性拯救停滞复制叉中展示其多功能的精湛技艺。
Cadenza ad libitum: cGAS and STING showcase their versatile virtuosities in the Ca-dependent rescue of stalled replication forks.
机构信息
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Mol Cell. 2023 Feb 16;83(4):502-503. doi: 10.1016/j.molcel.2023.01.021.
PMID:36804912
Abstract
In this issue of Molecular Cell, Li et al. report that the cGAS-STING cytosolic dsDNA sensing pathway plays a crucial role in regulating the TRPV2 calcium channel to rescue replication forks.
摘要
在本期《分子细胞》中,李等人报告称,cGAS-STING 细胞质双链 DNA 感应途径在调节 TRPV2 钙通道以拯救复制叉方面发挥着关键作用。