Azari Ali, Baradaran Rahimi Vafa, Moravvej Zahra, Rahsepar Amir Ali, Ghayour-Mobarhan Majid, Salehi Maryam, Bigdelu Leila
Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
J Basic Clin Physiol Pharmacol. 2023 Feb 20;34(3):365-370. doi: 10.1515/jbcpp-2022-0244. eCollection 2023 May 1.
Cardiac surgeries initiate oxidative stress, increasing organ dysfunction development and mortality. The present study investigated the superoxide dismutase (SOD) activity, as an antioxidant enzyme, in patients undergoing coronary artery bypass (CABG) and heart valve replacement surgeries.
A prospective study was performed on patients with proven coronary artery disease (CAD) or valvular heart disease (VHD) candidates for on- or off-pump CABG and valve replacement surgery. Serum SOD activity was measured preoperatively, at 24 h postoperatively, and at the time of discharge. In addition, echocardiography was performed before surgery and at discharge.
A total of 48, 51, and 47 patients were enrolled in the on-pump, off-pump CABG, and valve replacement groups, respectively. Baseline serum SOD activity showed no significant association with BMI, age, and blood pressure in either CAD or VHD patients. The SOD values decreased at the 24 h postoperative time and then increased at the time of discharge in all groups, except for a slight decrease in the on-pump group. The changes in serum SOD values were not significantly different for the three surgical groups.
The serum SOD activities fell significantly after CABG and valve replacement surgery. Further investigation is emphasized for the role of SOD in oxidative stress after cardiac surgery.
心脏手术会引发氧化应激，增加器官功能障碍的发生和死亡率。本研究调查了接受冠状动脉搭桥术（CABG）和心脏瓣膜置换手术患者中作为抗氧化酶的超氧化物歧化酶（SOD）活性。
对确诊为冠状动脉疾病（CAD）或心脏瓣膜病（VHD）且计划进行体外循环或非体外循环CABG及瓣膜置换手术的患者进行了一项前瞻性研究。术前、术后24小时及出院时测量血清SOD活性。此外，在手术前和出院时进行超声心动图检查。
分别有48、51和47例患者纳入体外循环CABG组、非体外循环CABG组和瓣膜置换组。CAD或VHD患者的基线血清SOD活性与BMI、年龄和血压均无显著相关性。除体外循环组略有下降外，所有组的SOD值在术后24小时下降，然后在出院时升高。三个手术组血清SOD值的变化无显著差异。
CABG和瓣膜置换手术后血清SOD活性显著下降。强调进一步研究SOD在心脏手术后氧化应激中的作用。
