Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama 700-8530, Japan.
Org Lett. 2023 Mar 10;25(9):1370-1374. doi: 10.1021/acs.orglett.3c00047. Epub 2023 Feb 24.
Catalytic CO reduction with phenylsilane under solvent-free conditions was linked with the one-pot synthesis of 3,4-dihydropyrans from β-dicarbonyl compounds and styrenes. The synthesis includes three processes: (1) bis(silyl)acetal formation from CO and phenylsilane and a domino reaction of (2) Knoevenagel condensation and (3) inverse-electron-demand oxa-Diels-Alder reaction. The first process was catalyzed by a pentanuclear Zn complex (0.07 mol %) to generate bis(silyl)acetals, which were hydrolyzed into formaldehyde to be used in the second step.
在无溶剂条件下，苯硅烷催化的一氧化碳还原与β-二羰基化合物和苯乙烯一锅法合成 3,4-二氢吡喃有关。该合成包括三个过程：（1）CO 和苯硅烷形成双（硅基）缩醛，以及（2）Knoevenagel 缩合和（3）逆电子需求的缺电子 Diels-Alder 反应的串联反应。第一个过程由五核锌配合物（0.07 mol%）催化生成双（硅基）缩醛，然后将其水解成甲醛，用于第二步。
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