衰老过程中脑细胞的遗传和表观遗传性别二态性

Genetic and Epigenetic Sexual Dimorphism of Brain Cells during Aging.

作者信息

Shirokova Olesya, Zaborskaya Olga, Pchelin Pavel, Kozliaeva Elizaveta, Pershin Vladimir, Mukhina Irina

机构信息

Institute of Fundamental Medicine, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603950, Russia.

Institute of Biology and Biomedicine, Lobachevsky State University, 23 Gagarin Avenue, Nizhny Novgorod 603002, Russia.

出版信息

Brain Sci. 2023 Jan 24;13(2):195. doi: 10.3390/brainsci13020195.

DOI:10.3390/brainsci13020195

PMID:36831738

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9954625/

Abstract

In recent years, much of the attention paid to theoretical and applied biomedicine, as well as neurobiology, has been drawn to various aspects of sexual dimorphism due to the differences that male and female brain cells demonstrate during aging: (a) a dimorphic pattern of response to therapy for neurodegenerative disorders, (b) different age of onset and different degrees of the prevalence of such disorders, and (c) differences in their symptomatic manifestations in men and women. The purpose of this review is to outline the genetic and epigenetic differences in brain cells during aging in males and females. As a result, we hereby show that the presence of brain aging patterns in males and females is due to a complex of factors associated with the effects of sex chromosomes, which subsequently entails a change in signal cascades in somatic cells.

摘要

近年来，由于男性和女性脑细胞在衰老过程中表现出的差异，理论和应用生物医学以及神经生物学的诸多关注都集中在了性二态性的各个方面：(a) 神经退行性疾病治疗反应的二态模式；(b) 此类疾病不同的发病年龄和不同程度的患病率；以及 (c) 男性和女性在症状表现上的差异。本综述的目的是概述男性和女性衰老过程中脑细胞的遗传和表观遗传差异。因此，我们在此表明，男性和女性大脑衰老模式的存在是由于与性染色体效应相关的一系列复杂因素，这随后导致体细胞中信号级联的变化。