Department of Industrial Engineering, School of Engineering and Architecture, Alma Mater Studiorum - Università di Bologna, Bologna, Italy.
In Silico Biomechanics Laboratory, National Center for Spinal Disorders, Királyhágó St. 1-3, Budapest, 1126, Hungary.
Sci Rep. 2023 Feb 25;13(1):3293. doi: 10.1038/s41598-023-27552-0.
Percutaneous Cement Discoplasty (PCD) is a minimally invasive surgical technique to treat degenerated intervertebral discs. When the disc is severely degenerated, the vacuum observed in place of the nucleus pulposus can be filled with bone cement to restore the disc height, open the foramen space, and relieve pain. This study aimed to evaluate the foramen geometry change due to PCD, in the loaded spine. Cadaveric spines (n = 25) were tested in flexion and extension while Digital Image Correlation (DIC) measured displacements and deformations. Tests were performed on simulated pre-operative condition (nucleotomy) and after PCD. Registering DIC images and the 3D specimen geometry from CT scans, a 3D model of the specimens aligned in the experimental pose was obtained for nucleotomy and PCD. Foramen space volume was geometrically measured for both conditions. The volume of cement injected was measured to explore correlation with the change of foramen space. PCD induced a significant overall foraminal decompression in both flexion (foramen space increased by 835 ± 1289 mm, p = 0.001) and extension (1205 ± 1106 mm, p < 0.001), confirming that the expected improvements of PCD show also during spine motion. Furthermore, in extension when the foramen is the most challenged, the impact of PCD on the foramen correlated with the injected cement volume.
经皮骨水泥椎间盘成形术(PCD)是一种治疗退行性椎间盘的微创手术技术。当椎间盘严重退化时,可以将观察到的真空部位用骨水泥填充,以恢复椎间盘高度、打开椎间孔并缓解疼痛。本研究旨在评估 PCD 引起的加载脊柱椎间孔几何形状的变化。在屈伸运动中测试了 25 个尸体脊柱,数字图像相关(DIC)测量了位移和变形。在模拟术前条件(髓核切除术)和 PCD 后进行了测试。通过 DIC 图像和 CT 扫描的 3D 标本几何图形注册,获得了在实验位置对齐的标本的 3D 模型,用于髓核切除术和 PCD。对两种情况的椎间孔空间体积进行了几何测量。测量了注射的水泥体积,以探讨与椎间孔空间变化的相关性。PCD 在屈伸位都显著地整体减压了椎间孔(椎间孔空间增加了 835±1289mm,p=0.001)和伸展位(增加了 1205±1106mm,p<0.001),证实了 PCD 的预期改善也在脊柱运动期间显示。此外,在伸展时椎间孔最受挑战时,PCD 对椎间孔的影响与注射的水泥体积相关。