Barnes M, Kasimanickam R, Kasimanickam V
College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Theriogenology. 2023 Apr 15;201:76-82. doi: 10.1016/j.theriogenology.2023.02.020. Epub 2023 Feb 20.
Fertility of recipient beef cows with subclinical endometritis (SCE) that did or did not receive flunixin meglumine (FM) treatment were compared following transfer of d 7 embryo. The study population comprised of 600 Angus cross cows that expressed estrus following Select-Synch + CIDR (Controlled Internal Drug Release) estrus synchronization protocol. At the time of embryo transfer, approximately 3 wk after sampling for subclinical endometritis, cows were randomly allocated either to receive FM treatment (500 mg of Banamine®; n = 300) or not (Control; n = 300). The effect of subclinical endometritis (at ≥ 1% PMN on endometrial cytology by cytobrush method) and FM treatment on pregnancy/embryo transfer (P/ET, %) were evaluated by mixed model. Of the 600 cows, 323 (53.8%) became pregnant; 55.0% (165/300) cows that received FM treatment vs. 52.7% (158/300) control cows (P > 0.1), and 55.9% (266/476) normal vs. 46.0% (57/124) subclinical endometritis cows (P < 0.05). There was a trend for treatment by subclinical endometritis for P/ET (P = 0.09). Pregnancy was recorded in 55.3% (134/242) of normal and 53.4% (31/58) of subclinical endometritis cows that received FM treatment, and in 56.4% (132/234) of normal and 39.4% (26/66) of subclinical endometritis cows that did not receive FM treatment (P = 0.09). In conclusion, subclinical endometritis in recipient beef cows resulted in lower P/ET. Though not significant in cows with subclinical endometritis, FM treatment resulted in 14.0% points more pregnancy compared with control.
在移植第7天的胚胎后，比较了患有或未患有亚临床子宫内膜炎（SCE）且接受或未接受氟尼辛葡甲胺（FM）治疗的受体肉牛的繁殖力。研究群体包括600头安格斯杂交母牛，这些母牛在采用Select-Synch + CIDR（可控内部药物释放）发情同步方案后表现出发情。在胚胎移植时，即采样检测亚临床子宫内膜炎大约3周后，母牛被随机分配接受FM治疗（500 mg Banamine®；n = 300）或不接受治疗（对照组；n = 300）。通过混合模型评估亚临床子宫内膜炎（通过细胞刷法检测子宫内膜细胞学中PMN≥1%）和FM治疗对妊娠/胚胎移植（P/ET，%）的影响。在600头母牛中，323头（53.8%）怀孕；接受FM治疗的母牛中有55.0%（165/300）怀孕，对照组母牛中有52.7%（158/300）怀孕（P>0.1），正常母牛中有55.9%（266/476）怀孕，亚临床子宫内膜炎母牛中有46.0%（57/124）怀孕（P<0.05）。亚临床子宫内膜炎对P/ET的治疗存在一定趋势（P = 0.09）。接受FM治疗的正常母牛中有55.3%（134/242）怀孕，亚临床子宫内膜炎母牛中有53.4%（31/58）怀孕；未接受FM治疗的正常母牛中有56.4%（132/234）怀孕，亚临床子宫内膜炎母牛中有39.4%（26/66）怀孕（P = 0.09）。总之，受体肉牛的亚临床子宫内膜炎导致较低的P/ET。虽然在患有亚临床子宫内膜炎的母牛中不显著，但与对照组相比，FM治疗使怀孕率提高了14.0个百分点。
