Iriki Hisato, Takahashi Hayato, Amagai Masayuki
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan; Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
J Invest Dermatol. 2023 Apr;143(4):545-553. doi: 10.1016/j.jid.2022.11.009. Epub 2023 Feb 25.
OX40 is an important costimulatory molecule for T-cell expansion and survival. Because OX40 is expressed on most T-cell subsets, it is an attractive therapeutic target for a variety of T-cell‒mediated diseases. Clinical trials are already underway for some skin inflammatory diseases. In this review, we present various observations that improve our understanding of how OX40-targeted therapy can be applied for skin inflammatory diseases, such as atopic dermatitis and psoriasis, T helper (Th)2- and Th17-mediated diseases, respectively. The important OX40/OX40L-mediated interaction between T cells and other immune cells is also discussed in terms of skin autoimmune diseases, such as alopecia areata and pemphigus. Regulatory T cells (Tregs) highly express OX40, and the skin harbors a large Treg population; thus, understanding how OX40-targeted treatment acts on Tregs is vital for the development of therapeutic strategies for various skin diseases.
OX40是T细胞增殖和存活的重要共刺激分子。由于OX40在大多数T细胞亚群上表达，它是治疗多种T细胞介导疾病的一个有吸引力的靶点。目前针对一些皮肤炎症性疾病的临床试验已经在进行。在这篇综述中，我们展示了各种观察结果，这些结果增进了我们对如何将OX40靶向治疗应用于皮肤炎症性疾病（如特应性皮炎和银屑病，分别由辅助性T细胞（Th）2和Th17介导的疾病）的理解。还从斑秃和天疱疮等皮肤自身免疫性疾病的角度讨论了重要的OX40/OX40L介导的T细胞与其他免疫细胞之间的相互作用。调节性T细胞（Tregs）高表达OX40，且皮肤中存在大量Treg群体；因此，了解OX40靶向治疗如何作用于Tregs对于开发各种皮肤疾病的治疗策略至关重要。
