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[慢性心力衰竭中衰弱障碍的临床特征]

[Clinical features of asthenic disorders in chronic heart failure].

作者信息

Fomicheva A V, Volel B A, Troshina D V, Andreev D A, Simonov A N, Zozulya S A, Klyushnik T P

机构信息

Sechenov First Moscow State Medical University, Moscow, Russia.

Mental Health Research Centre, Moscow, Russia.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(2):104-111. doi: 10.17116/jnevro2023123021104.

Abstract

OBJECTIVE

The aim of the study is to study the clinical features of asthenic disorders in chronic heart failure (CHF) considering the reaction to the disease.

MATERIAL AND METHODS

62 inpatients with CHF II-IV functional class (FC) according to NYHA were examined. Research methods included somatic, psychopathological and pathopsychological examination using psychometric scales.

RESULTS

According to a pathopsychological study using the Multidimensional Fatigue Inventory (MFI-20), asthenic disorders were discovered in all examined patients, realized mainly by «general fatigue» (75.8%) and «physical fatigue» (72.6%), more rarely «mental fatigue» was observed (32.2%). Correlations of «general fatigue» with the age of patients were revealed (=0.018). There was a relationship between the severity of asthenic disorders and the severity of CHF, as evidenced by the correlation between «general fatigue» and reduced ejection fraction (EF) of the left ventricle (=0.005), as well as «physical fatigue» and FC according to NYHA (=0.022). The negative impact of all components of the dimensions of asthenic disorders on the quality of life was determined (<0.05). According to the concept of the formation of different perceptions of the manifestations of a somatic disease, two types of reactions to asthenic disorders were identified: 1. Dissociative reactions, manifested by a discrepancy between the severity of CHF and a subjective assessment of the condition with an underestimation of the asthenic symptoms denial of its influence on the usual lifestyle and associated with an unfavorable course of CHF and 2. Adaptive reactions, realized by a harmonious perception of asthenia, awareness of the need to change lifestyle considering the presence of CHF symptoms.

CONCLUSION

In accordance with the results, the described clinical features of asthenic disorders allow to distinguish asthenia in CHF and other pathology, and the identified types of reactions can contribute to the timely verification of asthenia, prevention of further progression of CHF, and the development of appropriate treatment approaches.

摘要

目的

本研究旨在探讨慢性心力衰竭(CHF)中虚弱障碍的临床特征,并考虑患者对疾病的反应。

材料与方法

对62例根据纽约心脏协会(NYHA)心功能分级为II-IV级的CHF住院患者进行了检查。研究方法包括使用心理测量量表进行躯体、心理病理和病理心理检查。

结果

根据使用多维疲劳量表(MFI-20)进行的病理心理研究,在所有检查患者中均发现了虚弱障碍,主要表现为“全身疲劳”(75.8%)和“身体疲劳”(72.6%),较少观察到“精神疲劳”(32.2%)。发现“全身疲劳”与患者年龄之间存在相关性(=0.018)。虚弱障碍的严重程度与CHF的严重程度之间存在关联,“全身疲劳”与左心室射血分数(EF)降低之间的相关性(=0.005)以及“身体疲劳”与NYHA心功能分级之间的相关性(=0.022)均证明了这一点。确定了虚弱障碍各维度的所有组成部分对生活质量的负面影响(<0.05)。根据对躯体疾病表现形成不同认知的概念,确定了对虚弱障碍的两种反应类型:1.分离反应,表现为CHF严重程度与对病情的主观评估之间存在差异,低估虚弱症状,否认其对日常生活方式的影响,且与CHF的不良病程相关;2.适应性反应,通过对虚弱的和谐认知来实现,意识到考虑到CHF症状需要改变生活方式。

结论

根据研究结果,所描述的虚弱障碍临床特征有助于区分CHF中的虚弱与其他病理情况,所确定的反应类型有助于及时识别虚弱,预防CHF进一步进展,并制定适当的治疗方法。

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