Ichida F, Fatica N S, Engle M A, O'Loughlin J E, Klein A A, Snyder M S, Ehlers K H, Levin A R
Division of Pediatric Cardiology, New York Hospital-Cornell Medical Center, NY 10021.
Pediatrics. 1987 Dec;80(6):828-35.
Since January 1980, 110 children having 113 attacks of Kawasaki syndrome were studied. Age at onset was 7 weeks to 12 years (mean 3 6/12 years, median 2 9/12 years); 77% were younger than 5 years of age; the male to female ratio was 1.8; racial distribution was 52% white, 19% black, 14% Hispanic, and 16% Asian. Protocol of management consisted of high-dose aspirin (100 mg/kg/d) until afebrile, and then 81 mg every day until free of coronary aneurysm. Two-dimensional echocardiograms were done weekly during the acute stage, at 2 and 6 months after onset, and yearly if a coronary abnormality was detected. At 1 month, 51 coronary arterial abnormalities were present in 25 patients. Risk factors for a coronary abnormality were duration of fever greater than or equal to 2 weeks, level of platelet count, marked elevation of ESR, and age younger than 5 years. No statistically significant difference in incidence of aneurysms was detected between patients on high-dose aspirin and those on medium-or low-dose aspirin.
自1980年1月起，对110名患有113次川崎综合征发作的儿童进行了研究。发病年龄为7周龄至12岁（平均3.5岁，中位数2.75岁）；77%的患儿年龄小于5岁；男女比例为1.8；种族分布为52%白人、19%黑人、14%西班牙裔和16%亚裔。治疗方案包括在发热消退前给予大剂量阿司匹林（100mg/kg/天），然后每天给予81mg，直至无冠状动脉瘤。在急性期每周进行二维超声心动图检查，发病后2个月和6个月进行检查，如果检测到冠状动脉异常则每年检查一次。在1个月时，25名患者出现51处冠状动脉异常。冠状动脉异常的危险因素包括发热持续时间大于或等于2周、血小板计数水平、血沉显著升高以及年龄小于5岁。在接受大剂量阿司匹林治疗的患者与接受中剂量或低剂量阿司匹林治疗的患者之间，未检测到动脉瘤发生率的统计学显著差异。
