Department of Physics, College of Science, Mustansiriyah University, Baghdad, Iraq.
Department of Physics, College of Science, University of Baghdad, Baghdad, Iraq.
Arch Toxicol. 2023 Apr;97(4):1017-1031. doi: 10.1007/s00204-023-03462-y. Epub 2023 Feb 27.
Advancements in nanomedicine helped scientists design a new class of nanoparticles known as hybrid nanoparticles (core/shell) for diagnostic and therapeutic purposes. An essential requirement for the successful use of nanoparticles in biomedical applications is their low toxicity. Therefore, toxicological profiling is necessary to understand the mechanism of nanoparticles. The current study aimed to assess the toxicological potential of CuO/ZnO core/shell nanoparticles with a size of 32 nm in Albino female rats. In vivo toxicity was evaluated by oral administration of 0, 5, 10, 20, and 40 (mg/L) of CuO/ZnO core/shell nanoparticles to a female rate for 30 consecutive days. During the time of treatment, no deaths were observed. The toxicological evaluation revealed significant (p < 0.01) alteration in white blood cells (WBC) at a 5 (mg/L) dose. Also, increase in red blood cells (RBC) at 5, 10 (mg/L) doses, while hemoglobin (Hb) levels and hematocrit (HCT) increased at all doses. This maybe indicates that the CuO/ZnO core/shell nanoparticles stimulated the rate of blood corpuscle generation. The anaemia diagnostic indices (mean corpuscular volume MCV and mean corpuscular haemoglobin MCH) remained unchanged throughout the experiment for all the doses tested 5, 10, 20, and 40 (mg/L). According to the results of this study, exposure to CuO/ZnO core/shell NPs deteriorates the Triiodothyronine hormone (T3) and a Thyroxine hormone (T4) activated by Thyroid-Stimulating Hormone (TSH), which is generated and secreted from the pituitary gland. There is possibly related to an increase in free radicals and a decrease in antioxidant activity. Significant (p < 0.01) growth retardation in all groups treated due to rats' infection by Hyperthyroidism induced by thyroxine (T4) level increase. Hyperthyroidism is a catabolic state related to increased energy consumption, protein turnover, and lipolysis. Usually, these metabolic effects result in weight reduction and a decrease in fat storage and lean body mass. The histological examination indicates that the low concentrations of CuO/ZnO core/shell nanoparticles are safe for desired biomedical applications.
纳米医学的进步帮助科学家设计了一类新的纳米粒子，称为核壳型混合纳米粒子，用于诊断和治疗目的。将纳米粒子成功应用于生物医学领域的一个基本要求是其低毒性。因此，需要进行毒理学分析以了解纳米粒子的作用机制。本研究旨在评估粒径为 32nm 的 CuO/ZnO 核壳纳米粒子的毒理学潜力。通过口服给予雌性大鼠 0、5、10、20 和 40（mg/L）的 CuO/ZnO 核壳纳米粒子，连续 30 天进行体内毒性评估。在治疗期间，没有观察到死亡。毒理学评价显示，在 5（mg/L）剂量下，白细胞（WBC）显著（p<0.01）改变。此外，在 5、10（mg/L）剂量下红细胞（RBC）增加，而血红蛋白（Hb）水平和血细胞比容（HCT）在所有剂量下均增加。这可能表明 CuO/ZnO 核壳纳米粒子刺激了血细胞的生成速度。贫血诊断指标（平均红细胞体积 MCV 和平均红细胞血红蛋白 MCH）在整个实验过程中保持不变，所有测试剂量为 5、10、20 和 40（mg/L）。根据本研究结果，暴露于 CuO/ZnO 核壳 NPs 会破坏三碘甲状腺原氨酸激素（T3）和甲状腺刺激激素（TSH）激活的甲状腺素激素（T4），TSH 由垂体产生和分泌。这可能与自由基增加和抗氧化活性降低有关。由于甲状腺素（T4）水平升高导致的甲状腺功能亢进引起的大鼠感染，所有治疗组均出现明显（p<0.01）生长迟缓。甲状腺功能亢进是一种分解代谢状态，与能量消耗增加、蛋白质周转和脂肪分解有关。通常，这些代谢作用导致体重减轻和脂肪储存减少以及瘦体重减少。组织学检查表明，CuO/ZnO 核壳纳米粒子的低浓度对所需的生物医学应用是安全的。
Zotero 插件
