Kim Byungmi, Rhie Minshik, Park Sunhee, Kim Hyo-Seon, Kwon Jeoung A
Division of Cancer Prevention, National Cancer Control Institute, National Cancer Center, Goyang 10408, Republic of Korea.
Center of Tobacco Control, National Cancer Center, Goyang 10408, Republic of Korea.
Toxics. 2023 Jan 29;11(2):129. doi: 10.3390/toxics11020129.
Research on the association between blood cadmium (BCd) exposure and thyroid hormone levels in the general population has been inconclusive. Therefore, we examined the associations between BCd and thyroid hormones according to smoking status in Korean adults (N = 1170, Men = 722, Women = 448) using multiple linear regression and restricted cubic splines analysis with data from the Korean National Health and Nutrition Examination Survey (2013). The geometric mean of BCd was 0.74 μg/L in all study participants and was higher in smokers (1.01 μg/L) than in nonsmokers (0.65 μg/L). Restricted cubic splines analysis revealed nonlinear trends between BCd and free thyroxine in smokers ( for nonlinearity = 0.02). By contrast, there were no significant associations between BCd and thyroid hormones in either men or women. In conclusion, nonlinear associations may exist between BCd and free thyroxine in smokers. Our study provides empirical support for the future formulation of an acceptable concentration range of BCd and offers a new concept for preventing thyroid problems.
关于普通人群血液镉（BCd）暴露与甲状腺激素水平之间关联的研究尚无定论。因此，我们利用韩国国家健康与营养检查调查（2013年）的数据，通过多元线性回归和受限立方样条分析，研究了韩国成年人（N = 1170，男性 = 722，女性 = 448）中BCd与甲状腺激素之间根据吸烟状况的关联。所有研究参与者的BCd几何均值为0.74μg/L，吸烟者（1.01μg/L）高于非吸烟者（0.65μg/L）。受限立方样条分析显示吸烟者中BCd与游离甲状腺素之间存在非线性趋势（非线性检验P = 0.02）。相比之下，男性或女性中BCd与甲状腺激素之间均无显著关联。总之，吸烟者中BCd与游离甲状腺素之间可能存在非线性关联。我们的研究为未来制定BCd的可接受浓度范围提供了实证支持，并为预防甲状腺问题提供了新的概念。
