Burgess D R, Schroeder T E
Methods Achiev Exp Pathol. 1979;8:171-89.
The role of microfilaments and microtubules comprising the cytoskeleton and cytomusculature in embryonic development is discussed. The cytomusculature, as microfilaments, is evident in both the unfertilized and fertilized egg and probably plays a role in sperm incorporation, cortical contractions, and cytokinesis. The cytoskeleton, in the form of microtubules, appears after fertilization in the form of the sperm aster and the mitotic apparatus. The cytoskeleton and cytomusculature play a decisive role in shape changes of individual cells responsible for gastrulation, neurulation, and morphogenesis of other epithelial sheets. Several developmental defects, such as spina bifida, may be related to malfunctioning of the cytoskeleton or cytomusculature. The putative role of microfilaments and microtubules in cell shape changes during embryogenesis can best be, at least initially, inferred from careful ultrastructural observations.
本文讨论了构成细胞骨架和细胞肌肉组织的微丝和微管在胚胎发育中的作用。细胞肌肉组织，如微丝，在未受精卵和受精卵中均有体现，可能在精子融合、皮质收缩和胞质分裂中发挥作用。细胞骨架以微管的形式，在受精后以精子星体和有丝分裂器的形式出现。细胞骨架和细胞肌肉组织在负责原肠形成、神经胚形成和其他上皮层形态发生的单个细胞的形状变化中起决定性作用。一些发育缺陷，如脊柱裂，可能与细胞骨架或细胞肌肉组织功能失调有关。微丝和微管在胚胎发生过程中细胞形状变化中的假定作用，至少在最初，可以最好地从仔细的超微结构观察中推断出来。
Zotero 插件