Alkhiari Resheed, Alfadda Turky, Alashgar Meshal, Alrawaf Faisal, Alquraishi Abdulrahman, Alkhiari Khaled, Alrashedi Omar, Almutairi Nawaf, Albarrak Abdulmajeed, Alsahafi Majid
Department of Medicine, College of Medicine, Qassim University, Qassim, KSA.
College of Medicine, Qassim University, Qassim, KSA.
J Taibah Univ Med Sci. 2023 Jan 4;18(4):855-859. doi: 10.1016/j.jtumed.2022.12.018. eCollection 2023 Aug.
Colorectal cancer is a common cause of cancer-related mortality in KSA with a rising incidence. Although adenomatous polyps are well-recognized as precursors of colorectal cancer, local data are scarce. Therefore, in this study, we aimed to evaluate the characteristics of adenomatous colon polyps in the Saudi population.
We retrospectively reviewed the electronic databases of all patients who underwent colonoscopy for any indication between January 2015 and December 2019 at a tertiary care hospital. This study included adult patients who were found to have colorectal polyps with identified histopathology reports. We collected clinical and pathological data, including patient age, sex, and histopathological polyp characteristics. A p-value <0.05 was considered significant for descriptive and analytical statistics.
A total of 184 patients with colorectal polyps with identified histopathology reports were included in the analysis. Of these, 130 (70.6%) patients were aged 50 years or older, and 135 (73.3%) were male. Among all polyps, 127 (69%) were adenomatous, 31 (16.8%) were hyperplastic, and 24 (13%) were inflammatory. For adenomatous polyps, 31 (24.4%) were observed in patients younger than 50 years, and high-grade dysplasia was observed in 23 (18%) polyps. Among patients with adenomatous polyps, the anatomical location was as follows: 27 (23%) in the cecum/ascending colon, 12 (9%) in the transverse colon, 45 (35%) in the descending/sigmoid colon, 25 (19%) in the rectum, and 18 (14%) at multiple sites. Age >50 years was significantly associated with adenomatous polyps (P = 0.03).
Approximately one-third of adenomatous polyps were detected proximal to the splenic flexure. Although adenomatous polyps were significantly associated with increasing age, 24% were observed in patients younger than 50 years of age. This finding supports the current recommendation to start screening at the age of 45.
结直肠癌是沙特阿拉伯癌症相关死亡的常见原因，且发病率呈上升趋势。尽管腺瘤性息肉被公认为是结直肠癌的癌前病变，但当地数据稀缺。因此，在本研究中，我们旨在评估沙特人群中腺瘤性结肠息肉的特征。
我们回顾性分析了2015年1月至2019年12月期间在一家三级医院因任何适应症接受结肠镜检查的所有患者的电子数据库。本研究纳入了经组织病理学报告确诊患有结直肠息肉的成年患者。我们收集了临床和病理数据，包括患者年龄、性别以及组织病理学息肉特征。描述性和分析性统计中，p值<0.05被认为具有统计学意义。
共有184例经组织病理学报告确诊患有结直肠息肉的患者纳入分析。其中，130例（70.6%）患者年龄在50岁及以上，135例（73.3%）为男性。在所有息肉中，127例（69%）为腺瘤性，31例（16.8%）为增生性，24例（13%）为炎性。对于腺瘤性息肉，31例（24.4%）在50岁以下患者中被观察到，23例（18%）息肉存在高级别异型增生。在患有腺瘤性息肉的患者中，解剖位置如下：盲肠/升结肠27例（23%），横结肠12例（9%），降结肠/乙状结肠45例（35%），直肠25例（19%），多个部位18例（14%）。年龄>50岁与腺瘤性息肉显著相关（P = 0.03）。
约三分之一的腺瘤性息肉在脾曲近端被检测到。尽管腺瘤性息肉与年龄增长显著相关，但24%在50岁以下患者中被观察到。这一发现支持了目前45岁开始筛查的建议。
