Shandong University of Traditional Chinese Medicine, Jinan, China,
Shandong University of Traditional Chinese Medicine, Jinan, China.
Ophthalmic Res. 2023;66(1):706-716. doi: 10.1159/000529639. Epub 2023 Feb 28.
The aim of this study was to quantitatively assess fundus tessellated density (FTD) and associated factors by artificial intelligence (AI) in young adults.
A total of 1,084 undergraduates (age, 17-23 years old) were enrolled in November 2021. The students were divided into three groups according to axial length (AL): group 1 (AL <24.0 mm, n = 155), group 2 (24 mm ≤ AL <26 mm, n = 578), and group 3 (AL ≥26 mm, n = 269). FTD was calculated by extracting the fundus tessellations as the regions of interest (circle 1, diameter of 3.0 mm; circle 2, diameter of 6.0 mm) and then calculating the average exposed choroid area per unit area of fundus.
Among 1,084 students, 1,002 (92.5%) students' FTDs were extracted. The mean FTD was 0.06 ± 0.06 (range, 0-0.40). In multivariate analysis, FTD was significantly associated with male sex, longer AL, thinner subfoveal choroid thickness (SFCT), increased choriocapillaris vessel density (VD), and decreased deeper choroidal VD (all p < 0.05). In circle 1 (diameter of 3.0 mm) and circle 2 (diameter of 6.0 mm), analysis of variance showed that the FTD of the nasal region (p < 0.05) was significantly larger than that of the superior, inferior, and temporal regions.
AI-based imaging processing could improve the accuracy of fundus tessellation diagnosis. FTD was significantly associated with a longer AL, thinner SFCT, increased choriocapillaris VD, and decreased deeper choroidal VD.
本研究旨在通过人工智能(AI)定量评估年轻人的眼底镶嵌密度(FTD)及其相关因素。
2021 年 11 月共纳入 1084 名大学生(年龄 17-23 岁)。根据眼轴(AL)将学生分为三组:组 1(AL <24.0mm,n=155)、组 2(24mm≤AL <26mm,n=578)和组 3(AL≥26mm,n=269)。通过提取作为感兴趣区域的眼底镶嵌图来计算 FTD(直径 3.0mm 的圆 1;直径 6.0mm 的圆 2),然后计算单位眼底面积暴露脉络膜的平均面积。
在 1084 名学生中,提取了 1002 名(92.5%)学生的 FTD。平均 FTD 为 0.06±0.06(范围 0-0.40)。多变量分析显示,FTD 与男性、较长的 AL、较薄的黄斑中心凹下脉络膜厚度(SFCT)、增加的脉络膜毛细血管血管密度(VD)以及较深脉络膜 VD 减少显著相关(均 p <0.05)。在直径 3.0mm 的圆 1 和直径 6.0mm 的圆 2 中,方差分析显示,鼻侧区域的 FTD(p <0.05)明显大于上、下和颞侧区域。
基于 AI 的成像处理可以提高眼底镶嵌诊断的准确性。FTD 与较长的 AL、较薄的 SFCT、增加的脉络膜毛细血管 VD 和减少的较深脉络膜 VD 显著相关。