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New insights into the mechanisms of anandamide-induced airway dilation placing its degradation enzyme, FAAH center stage. Commentary on: Simon A, von Einem T, Seidinger A, Matthey M, Bindila L, Wenzel D (2022) The endocannabinoid anandamide is an airway relaxant in health and disease. Nat Commun 13:6941.

作者信息

Pfitzer Gabriele

机构信息

Institute of Vegetative Physiology, Medical Faculty, University of Cologne, Robert-Koch-Str. 39, 50931, Cologne, Germany.

出版信息

Pflugers Arch. 2023 May;475(5):557-559. doi: 10.1007/s00424-023-02802-2. Epub 2023 Mar 1.

Abstract
摘要

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本文引用的文献

1
The endocannabinoid anandamide is an airway relaxant in health and disease.
Nat Commun. 2022 Nov 17;13(1):6941. doi: 10.1038/s41467-022-34327-0.
2
3
Untapped Potential: Therapeutically Targeting Eicosanoids and Endocannabinoids in the Lung.
Clin Pharmacol Ther. 2021 Jul;110(1):69-81. doi: 10.1002/cpt.2165. Epub 2021 Feb 13.
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Molecular Mechanism and Cannabinoid Pharmacology.
Handb Exp Pharmacol. 2020;258:323-353. doi: 10.1007/164_2019_298.
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The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite.
Pharmacol Res. 2016 Mar;105:152-63. doi: 10.1016/j.phrs.2016.01.023. Epub 2016 Jan 22.
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The effects of cannabidiol on the antigen-induced contraction of airways smooth muscle in the guinea-pig.
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Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma.
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Lipid metabolites as regulators of airway smooth muscle function.
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Inhaled anandamide reduces leukotriene D4-induced airway obstruction in guinea pigs.
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Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways.
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