Fan Meng-Yue, Chi Cheng, Zhang Jia-Hao, Wang Rui-Xue, Kong Qing-Yue, Wang Tai-Yi, Yan Jing-Lan, Chen Yong-Jun
Institute of Acupuncture and Moxibustion, Shandong University of TCM, Jinan 250355, China.
Zhongguo Zhen Jiu. 2023 Mar 12;43(3):269-76. doi: 10.13703/j.0255-2930.20221103-k0001.
Based on data mining technology, the acupoints compatibility rules of acupuncture for depression diseases were explored. The randomized controlled trial (RCT) articles regarding acupuncture for depression diseases published from establishment of database to September 2nd, 2022 were searched in CNKI database, Wangfang database, VIP database, SinoMed database, PubMed, EMbase, Web of Science and Cochrane Library. The use frequency of acupoints, meridian tropism, selection of special acupoints and acupoint association rules for five common depression diseases, including primary depression, post-stroke depression, menopausal syndrome, psychoneurosis and anxiety disorder, were analyzed by Python programming language. Cytoscape software was used to analyze the acupoint association and the disease-acupoint co-occurrence network. As a result, totally 387 articles were included, and 319 acupoints prescriptions for the above five common depression diseases were extracted, involving 159 acupoints. The use frequency of acupoints was 2 574 times in total. The frequently-used acupoints were Baihui (GV 20), Sanyinjiao (SP 6), Taichong (LR 3), Neiguan (PC 6), Shenmen (HT 7), Yintang (GV 24), Zusanli (ST 36), Hegu (LI 4), Sishencong (EX-HN 1) and Taixi (KI 3), etc. The frequently involved meridians were the governor vessel, foot- bladder meridian, foot- spleen meridian, and foot- liver meridian. The frequency of the special acupoints from high to low was crossing points, five- points, -primary points, back- points, -connecting points, and eight confluent points, etc, which were often used in combination with "Baihui (GV 20)-Yintang (GV 24)" (the highest degree of association). At the same time, the analysis of the co-occurrence network of depression diseases and acupoints showed that the core acupoints group of acupuncture for depression diseases were Baihui (GV 20), Taichong (LR 3), Shenmen (HT 7), Zusanli (ST 36), Neiguan (PC 6) and Sanyinjiao (SP 6). In conclusion, acupuncture treatment for depression diseases has gradually formed a rule of acupoint compatibility, with special acupoint as the main body and "unblocking the governor vessel, and regulating the spirit and " as the main therapeutic principle.
基于数据挖掘技术，探索针刺治疗抑郁症的穴位配伍规律。检索中国知网数据库、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、EMbase、Web of Science及Cochrane图书馆中自建库至2022年9月2日发表的关于针刺治疗抑郁症的随机对照试验（RCT）文献。采用Python编程语言分析原发性抑郁症、脑卒中后抑郁症、更年期综合征、神经官能症、焦虑症5种常见抑郁症的穴位使用频次、经络归经、特定穴选用及穴位关联规则。使用Cytoscape软件分析穴位关联及病证-穴位共现网络。结果，共纳入387篇文献，提取上述5种常见抑郁症的319首穴位处方，涉及159个穴位，穴位总使用频次为2574次。常用穴位有百会（GV20）、三阴交（SP6）、太冲（LR3）、内关（PC6）、神门（HT7）、印堂（GV24）、足三里（ST36）、合谷（LI4）、四神聪（EX-HN1）、太溪（KI3）等。高频涉及经络为督脉、足太阳膀胱经、足太阴脾经、足厥阴肝经。特定穴使用频次由高到低依次为交会穴、五输穴、原穴、背俞穴、络穴、八脉交会穴等，常以“百会（GV20）-印堂（GV24）”组合使用（关联度最高）。同时，抑郁症病证-穴位共现网络分析显示，针刺治疗抑郁症的核心穴位组合为百会（GV20）、太冲（LR3）、神门（HT7）、足三里（ST36）、内关（PC6）、三阴交（SP6）。结论：针刺治疗抑郁症逐渐形成了以特定穴为主体，以“疏通督脉、调神理气”为主要治疗原则的穴位配伍规律。
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