Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China.
Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns Research, Shijiazhuang 050091, China.
Biochem Cell Biol. 2023 Apr 1;101(2):148-159. doi: 10.1139/bcb-2022-0331. Epub 2023 Mar 2.
Nuclear receptor 4A1 (NR4A1), a member of the NR4A subfamily, acts as a gene regulator in a wide range of signaling pathways and responses to human diseases. Here, we provide a brief overview of the current functions of NR4A1 in human diseases and the factors involved in its function. A deeper understanding of these mechanisms can potentially improve drug development and disease therapy.
核受体 4A1(NR4A1)是 NR4A 亚家族的成员,作为基因调节剂在广泛的信号通路和对人类疾病的反应中发挥作用。在这里,我们简要概述了 NR4A1 在人类疾病中的当前功能以及其功能涉及的因素。对这些机制的更深入了解可能会提高药物开发和疾病治疗的效果。