年轻大麻使用者急性心肌梗死发病率呈上升趋势：一项为期10年的全国性性别和种族分层分析。

Rising trend of acute myocardial infarction among young cannabis users: A 10-year nationwide gender and race stratified analysis.

作者信息

Sandhyavenu Harigopal, Patel Harsh P, Patel Riddhiben H, Desai Rohan, Patel Achint A, Patel Bhavin A, Patel Jaimin, Zahid Salman, Khan Safi U, Deshmukh Abhishek, Nasir Khurram, DeSimone Christopher V, Dani Sourbha S, Thakkar Samarthkumar

机构信息

Department of Internal Medicine, Louis A Weiss Memorial Hospital, Chicago, IL, USA.

Department of Internal Medicine, HCA Medical City Arlington, Dallas, Tx, USA.

出版信息

Int J Cardiol Cardiovasc Risk Prev. 2022 Dec 29;16:200167. doi: 10.1016/j.ijcrp.2022.200167. eCollection 2023 Mar.

DOI:10.1016/j.ijcrp.2022.200167

PMID:36874042

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9975233/

Abstract

BACKGROUND

The use of cannabis has massively increased among younger patients due to increasing legalization and availability.

METHODS

We performed a retrospective nationwide study using the Nationwide inpatient sample (NIS) database to analyze the trends of acute myocardial infarction (AMI) in young cannabis users and related outcomes among patients aged 18-49 years from 2007 to 2018, using ICD-9 and ICD-10 codes.

RESULTS

Out of 819,175 hospitalizations, 230,497 (28%) admissions reported using cannabis. There was a significantly higher number of males (78.08% vs. 71.58%, p < 0.0001) and African Americans (32.22% vs. 14.06%, p < 0.0001) admitted with AMI and reported cannabis use. The incidence of AMI among cannabis users consistently increased from 2.36% in 2007 to 6.55% in 2018. Similarly, the risk of AMI in cannabis users among all races increased, with the biggest increase in African Americans from 5.69% to 12.25%. In addition, the rate of AMI in cannabis users among both sexes showed an upward trend, from 2.63% to 7.17% in males and 1.62%-5.12% in females.

CONCLUSION

The incidence of AMI in young cannabis users has increased in recent years. The risk is higher among males and African Americans.

摘要

背景

由于大麻合法化程度提高且获取更加容易，大麻在年轻患者中的使用量大幅增加。

方法

我们使用全国住院样本（NIS）数据库进行了一项全国性回顾性研究，利用国际疾病分类第九版（ICD - 9）和国际疾病分类第十版（ICD - 10）编码，分析2007年至2018年18至49岁年轻大麻使用者急性心肌梗死（AMI）的趋势及相关结果。

结果

在819,175例住院病例中，230,497例（28%）入院患者报告使用过大麻。因AMI入院且报告使用过大麻的男性（78.08%对71.58%，p < 0.0001）和非裔美国人（32.22%对14.06%，p < 0.0001）数量显著更多。大麻使用者中AMI的发病率从2007年的2.36%持续上升至2018年的6.55%。同样，所有种族中大麻使用者发生AMI的风险均增加，非裔美国人增加幅度最大，从5.69%增至12.25%。此外，大麻使用者中男女AMI发生率均呈上升趋势，男性从2.63%升至7.17%，女性从1.62%升至5.12%。