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是阿片类药物而非脊柱外科医生;全髋关节置换术后脱位与既往有腰椎融合术患者使用阿片类药物有关。

It is the Opioids Not the Spine Surgeon; Dislocation After Total Hip Arthroplasty is Associated With Opioid Use in Patients Who Have Prior Lumbar Spine Fusion.

作者信息

Kagan Ryland, Welling Sebastian, Mildren Mark E, Smith Spencer, Philipp Travis, Yoo Jung

机构信息

Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, Oregon.

Slocum Orthopaedic Center, Eugene, Oregon.

出版信息

J Arthroplasty. 2023 Jul;38(7 Suppl 2):S336-S339. doi: 10.1016/j.arth.2023.02.080. Epub 2023 Mar 6.

Abstract

BACKGROUND

Patients who have prior lumbar spine fusion (LSF) have an increased risk for dislocation after total hip arthroplasty (THA). These patients also have elevated rates of opioid use. We aimed to evaluate the associated risk of dislocation after THA in patients who have prior LSF comparing those who have opioid use to those who do not.

METHODS

This was a retrospective review using a large national database of 246,617 primary and 34,083 revision THA cases from 2012 to 2019. There were 1,903 primary THA and 288 revision THA cases identified with LSF prior to THA. Postoperative hip dislocation was our primary outcome variable and patients were stratified to use or nonuse of opioid at THA. Demographic data including age, sex, and obesity were collected. Multivariate analyses evaluated association of opioid use and dislocation after adjusting for demographics.

RESULTS

There was increased odds of dislocation for opioid use at THA for both primary (adjusted Odds Ratio [aOR] = 2.29, 95% Confidence Interval [CI] 1.46 to 3.57, P < .0003) and revision THA (aOR = 1.92, 95% CI 1.62 to 3.08, P < .0003), in patients who have prior LSF. Prior LSF without opioid use was associated with increased odds of dislocation (aOR = 1.38, 95% CI 1.01 to 1.88, P = .04), but this was lower than the associated risk of opioid use without LSF (aOR 1.72, 95% CI 1.63 to 1.81, P < .001).

CONCLUSION

Increased odds of dislocation were noted with opioid use at time of THA in patients who have prior LSF. Associated risk of dislocation was higher for opioid use than prior LSF. This suggests that dislocation risk is multifactorial and we should look to strategies to reduce opioid use prior to THA.

摘要

背景

既往有腰椎融合术(LSF)的患者在全髋关节置换术(THA)后发生脱位的风险增加。这些患者的阿片类药物使用比例也较高。我们旨在评估既往有LSF的患者在THA后发生脱位的相关风险,比较使用阿片类药物的患者和未使用阿片类药物的患者。

方法

这是一项回顾性研究,使用了一个大型国家数据库,该数据库包含2012年至2019年的246,617例初次THA病例和34,083例翻修THA病例。有1,903例初次THA病例和288例翻修THA病例在THA前被确定有LSF。术后髋关节脱位是我们的主要结局变量,患者被分为THA时使用或未使用阿片类药物。收集了包括年龄、性别和肥胖在内的人口统计学数据。多变量分析在调整人口统计学因素后评估了阿片类药物使用与脱位的相关性。

结果

对于既往有LSF的患者,在初次THA(调整后的优势比[aOR]=2.29,95%置信区间[CI]1.46至3.57,P<.0003)和翻修THA(aOR=1.92,95%CI 1.62至3.08,P<.0003)中,THA时使用阿片类药物的脱位几率均增加。既往有LSF但未使用阿片类药物与脱位几率增加相关(aOR=1.38,95%CI 1.01至1.88,P=.04),但低于无LSF时使用阿片类药物的相关风险(aOR 1.72,95%CI 1.63至1.81,P<.001)。

结论

既往有LSF的患者在THA时使用阿片类药物会增加脱位几率。使用阿片类药物的脱位相关风险高于既往有LSF。这表明脱位风险是多因素的,我们应寻求在THA前减少阿片类药物使用的策略。

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