Ross J A, Green H L
Division of Anaesthesia, Clinical Research Centre, Harrow, Middlesex, UK.
Br J Ind Med. 1987 Nov;44(11):764-8. doi: 10.1136/oem.44.11.764.
An investigation was undertaken to determine the ventricular fibrillation (VF) threshold of anaesthetised dogs subjected to external application of electric shocks between a foreleg and a hindleg. The shocks were 2-15 ms sections of 50 Hz sine waveform starting at peak current and were applied at a known time in the heart cycle. The object of the experiment was to determine if there was an increase in cardiac susceptibility to electrically induced VF at 31 atmospheres absolute (atm abs) in a helium and oxygen environment. The duration and position of that part of the cardiac cycle most vulnerable to induction of VF by electrocution was found (seven animals) using 4 ms shocks and then the minimum fibrillating current for shocks of 2-15 ms (min FC2-15) delivered at the most vulnerable point of the cycle (five animals). Body resistance was calculated from the data so gathered. Fibrillation thresholds were not changed by compression and there were no significant changes in the vulnerable period of the cardiac cycle. Min FC2 was significantly higher than for other durations under both control (3.21 A, SD 1.08) and test conditions (3.26 A, SD 0.39), p = 0.001. There was no difference in body resistance at 31 atm abs (395.5, SD 12.9) from control values at 1 atm abs (396.7, SD 10.9). From these data it was concluded that the heart is no more susceptible to the induction of VF at 31 atm abs in a helium oxygen environment and additional safety factors are unnecessary from this point of view.
进行了一项研究,以确定在前肢和后肢之间施加外部电击的麻醉犬的室颤(VF)阈值。电击为50Hz正弦波形的2 - 15ms片段,从峰值电流开始,并在心动周期的已知时间施加。该实验的目的是确定在31个绝对大气压(atm abs)的氦氧环境中,心脏对电诱导室颤的易感性是否增加。使用4ms电击找到了心动周期中最易被电刺激诱发室颤的部分的持续时间和位置(7只动物),然后在心动周期的最易损点施加2 - 15ms电击的最小致颤电流(min FC2 - 15)(5只动物)。根据收集到的数据计算身体电阻。压缩不会改变室颤阈值,心动周期的易损期也没有显著变化。在对照(3.21A,标准差1.08)和测试条件(3.26A,标准差0.39)下,min FC2均显著高于其他持续时间,p = 0.001。31 atm abs时的身体电阻(395.5,标准差12.9)与1 atm abs时的对照值(396.7,标准差10.9)没有差异。从这些数据得出结论,在氦氧环境中,心脏在31 atm abs时对室颤诱发的易感性并不更高,从这个角度来看不需要额外的安全因素。