内源性血管加压素影响人体血压的姿势控制。

Endogenous vasopressin affects postural control of blood pressure in man.

Simpson H C, Zubillaga J E, Collier J G, Bennett E D, Mehta N, Ang V T, Jenkins J S

Department of Medicine, St George's Hospital Medical School, London.

Clin Sci (Lond). 1987 Dec;73(6):589-92. doi: 10.1042/cs0730589.

Abstract

Six healthy volunteers received intravenous infusions of isotonic (0.9% NaCl) and hypertonic (3% NaCl) saline on separate days. There were no significant changes in blood pressure or forearm blood flow, despite an increase in plasma arginine vasopressin (AVP) during hypertonic saline. 2. Immediately and 10 min after passive tilting to 50 degrees, mean forearm blood flow fell by 17.1 and 14.3% compared with the values in the supine position during isotonic saline and by 40.3 and 43.3% during hypertonic saline. Forearm vascular resistance rose by 23.6 and 17.8% with isotonic saline and by 80.2 and 88.2% with hypertonic saline for the two readings in the tilted compared with the supine position. 3. Tilting was associated with a 14.9 and 12.1% rise in diastolic blood pressure immediately and 10 min after assuming this position during hypertonic saline, and a rise of 6.4% in mean arterial pressure. 4. The results from this study are similar to those obtained previously, when small amounts of AVP were infused. They provide further evidence that AVP may have a physiological role in the postural regulation of blood pressure.

摘要

六名健康志愿者在不同日期分别接受了等渗（0.9%氯化钠）和高渗（3%氯化钠）盐水的静脉输注。尽管在输注高渗盐水期间血浆精氨酸加压素（AVP）有所增加，但血压和前臂血流量均无显著变化。2. 在被动倾斜至50度后即刻和10分钟时，与等渗盐水输注期间仰卧位的值相比，平均前臂血流量分别下降了17.1%和14.3%，而在高渗盐水输注期间则下降了40.3%和43.3%。与仰卧位相比，在倾斜位时，等渗盐水两次测量的前臂血管阻力分别上升了23.6%和17.8%，高渗盐水则分别上升了80.2%和88.2%。3. 在高渗盐水输注期间，倾斜至该位置后即刻和10分钟时，舒张压分别升高了14.9%和12.1%，平均动脉压升高了6.4%。4. 本研究的结果与先前输注少量AVP时获得的结果相似。它们进一步证明AVP可能在血压的姿势调节中具有生理作用。