Aradhyam Gopala Krishna, Jagannathan Naranamangalam R
Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India.
Koita Centre for Digital Health (KCDH), Indian Institute of Technology Bombay, Mumbai, India.
Biophys Rev. 2023 Feb 13;15(1):71-73. doi: 10.1007/s12551-023-01045-w. eCollection 2023 Feb.
Gobind Khorana's distinguished career spanned nearly six decades (1952-2011). His work resulted in remarkable achievements starting with the complicated synthesis of coenzyme A. He then pioneered the synthesis of DNA oligonucleotides, which enabled him to crack the genetic code. Using this experience, he ventured to accomplish the first complete synthesis of a gene. Not satisfied with elucidating the function of bacteriorhodopsin, Gobind took up another greater challenge, that of spearheading studies on visual rhodopsin, its mechanism of activation, and the consequent signal transduction pathway. This Editorial acts to introduce the articles appearing in this Issue Focus dedicated to celebrating the 100th anniversary of the year of his birth.
戈宾德·科拉纳卓越的职业生涯跨越了近六十年（1952年至2011年）。他的工作取得了非凡成就，始于辅酶A的复杂合成。随后，他率先合成了DNA寡核苷酸，这使他能够破解遗传密码。凭借这一经验，他大胆尝试完成了基因的首次全合成。戈宾德并不满足于阐明细菌视紫红质的功能，他又接受了另一项更大的挑战，即率先开展对视觉视紫红质、其激活机制以及随之而来的信号转导途径的研究。这篇社论旨在介绍本期专刊中发表的文章，以纪念他诞辰100周年。
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