Department of Psychiatry, Stanford University School of Medicine, Stanford, California, USA.
Curr Opin Obstet Gynecol. 2023 Apr 1;35(2):150-153. doi: 10.1097/GCO.0000000000000857. Epub 2023 Feb 7.
The purpose of this review is to provide an update on the most recent research regarding potential causes and treatments for perimenopausal depression.
Erratic estrogen fluctuations and alterations in the neurosteroid allopregnanolone are important contributors to perimenopausal mood symptoms. These hormone changes augment increased risk associated with recent stressful events, as well as early life childhood events. Perimenopausal depressions have different clinical presentations and may respond to differential treatment approaches.
Future research should focus on these recent findings of interindividual hormonal sensitivity, childhood trauma histories, and varying depression symptom profiles for a personalized treatment approach to perimenopausal depression.
本文旨在提供围绝经期抑郁症的潜在病因和治疗的最新研究进展。
雌激素波动不定和神经甾体别孕烯醇酮改变是围绝经期情绪症状的重要原因。这些激素变化增加了与近期应激事件以及早期生活中儿童期事件相关的风险。围绝经期抑郁症有不同的临床表现，可能对不同的治疗方法有反应。
未来的研究应集中在个体激素敏感性、儿童期创伤史以及围绝经期抑郁症不同的抑郁症状谱这些最新发现上，为围绝经期抑郁症的个体化治疗方法提供依据。
