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巴勒斯坦西岸医疗服务学生缺乏药物基因组学教育。

Lack of exposure to pharmacogenomics education among the health care providing students in the West Bank of Palestine.

机构信息

Department of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, Al-Salt, Jordan.

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.

出版信息

Drug Metab Pers Ther. 2023 Mar 13;38(3):267-272. doi: 10.1515/dmpt-2022-0180. eCollection 2023 Sep 1.

Abstract

OBJECTIVES

Evaluating the knowledge in pharmacogenomics (PGx) is the first step toward the implementation of PGx testing in clinical practice. This survey aimed to evaluate the knowledge of PGx testing among healthcare providing students at the top-ranked university in the West Bank of Palestine.

METHODS

First an online questionnaire consisting of 30 questions regarding the demographic, knowledge, and attitude toward pharmacogenomics testing was structured and validated. Then the questionnaire was distributed to 1,000 current students from different fields.

RESULTS

696 responses was received. The results showed that almost half of the participants (n=355, 51.1%) have never took any courses about PGx during their university training. Only 81 (11.7%) of the students who took the PGx course stated that it helped them understanding how genetic variations affect drug response. The majority of the students were uncertain (n=352, 50.6%) or disagreed (n=143, 20.6%) that the lectures during university education described the effects of genetic variants on drug response. Although most of the students (70-80%) answered that genetic variants can indeed affect the drug's response, only 162 students (23.3%) responded that and genotypes influence the response to warfarin. In addition, only 94 (13.5%) students were aware that many medicine labels include clinical information about PGx testing provided by the FDA.

CONCLUSIONS

It is concluded from the results of this survey that there is a lack of exposure to PGx education associated with poor knowledge of PGx testing among the healthcare providing students in the West Bank of Palestine. It is recommended to include and improve the lectures and courses regarding PGx as this will have a major impact on precision medicine.

摘要

目的

评估药物基因组学(PGx)知识是将 PGx 测试付诸临床实践的第一步。本调查旨在评估巴勒斯坦西岸排名第一的大学的医疗保健专业学生对 PGx 测试的知识。

方法

首先,我们构建并验证了一个包含 30 个问题的关于人口统计学、知识和对药物基因组学测试态度的在线问卷。然后,将问卷分发给来自不同领域的 1000 名当前学生。

结果

共收到 696 份回复。结果表明,近一半的参与者(n=355,51.1%)在大学培训期间从未参加过任何关于 PGx 的课程。仅 81 名(11.7%)参加过 PGx 课程的学生表示,这有助于他们了解遗传变异如何影响药物反应。大多数学生(n=352,50.6%)或不同意(n=143,20.6%)大学教育期间的讲座描述了遗传变异对药物反应的影响。尽管大多数学生(70-80%)回答遗传变异确实可以影响药物的反应,但只有 162 名学生(23.3%)回答说和基因型影响华法林的反应。此外,只有 94 名(13.5%)学生意识到许多药品标签包含 FDA 提供的关于 PGx 测试的临床信息。

结论

从这项调查的结果可以得出结论,巴勒斯坦西岸的医疗保健专业学生缺乏与 PGx 测试相关的教育接触,导致他们对 PGx 测试的知识水平较差。建议包括并改进关于 PGx 的讲座和课程,因为这将对精准医学产生重大影响。

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