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[从患有格林氏癌的大鼠血浆中分离出的氨基酸与氨基葡萄糖的结合物]

[Conjugates of amino acids with glucosamine isolated from the plasma of rats with Guerin carcinoma].

作者信息

Glinskiĭ G V, Vinnitskiĭ V B

出版信息

Eksp Onkol. 1987;9(5):78-80.

PMID:3691400
Abstract

The conjugate of amino acids and glucosamine (glycamine) was purified to homogeneity from blood plasma of rats with Guerin carcinoma. The NH2-groups of amino acids in the glycamine are free. Amino acids are linked to glucosamine via carboxyl groups. 8 amino acids residues were identified in the glycamine molecule (Glu-2, Ser-2, Gly-3, Lys-1). Spatial atomic-molecular model of the glycamine molecule was developed. Two glucosamine molecules are linked to diaminosaccharide via (1-4)-bond, 8 amino acid molecules are linked to diaminosaccharide via 6 ester and 2 pseudopeptide bonds.

摘要

从患格林癌大鼠的血浆中纯化出氨基酸与氨基葡萄糖(糖胺)的结合物,使其达到同质。糖胺中氨基酸的氨基是游离的。氨基酸通过羧基与氨基葡萄糖相连。在糖胺分子中鉴定出8个氨基酸残基(谷氨酸-2、丝氨酸-2、甘氨酸-3、赖氨酸-1)。构建了糖胺分子的空间原子-分子模型。两个氨基葡萄糖分子通过(1-4)键与二氨基糖相连,8个氨基酸分子通过6个酯键和2个假肽键与二氨基糖相连。

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