Hoyer Sebastian, Makridis Konstantin L, Atalay Deniz A, Thomale Ulrich-W, Prager Christine, Elger Christian E, Kaindl Angela M
Department of Pediatric Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Center for Chronically Sick Children, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Neuropediatrics. 2023 Jun;54(3):182-187. doi: 10.1055/s-0043-1764215. Epub 2023 Mar 15.
Family burden (FB) in pediatric patients with drug-resistant epilepsy (DRE) is significantly higher than that in children with non-DRE. Epilepsy surgery is an established approach to treat DRE, and this study examines the impact of pediatric epilepsy surgery on FB.
We retrospectively analyzed data of families and pediatric patients with focal structural DRE treated with epilepsy surgery at our epilepsy center from April 2018 to November 2021. We examined the relationship between cognitive, behavioral, and epilepsy-specific data and the FB measured with the German version of the Impact on Family Scale before and after epilepsy surgery.
The study cohort included 31 children with DRE at a mean age of 9 years at surgery (range = 0-16) and a mean epilepsy duration of 3 years (range = 0-14). Cognitive impairment correlated with FB in children with DRE prior to surgery. At the last assessment, 14.5 months (mean, range = 6-24) after epilepsy surgery, 87.2% of patients were seizure-free, FB values had decreased by 75.0%, and behavioral problems had decreased by 85,7%. Cognitive functions remained stable following epilepsy surgery.
In children with DRE, epilepsy surgery reduces FB. Given the considerable impact of families on the development and wellbeing of their children, the impact of epilepsy surgery should be communicated to affected families.
耐药性癫痫（DRE）患儿的家庭负担（FB）显著高于非DRE患儿。癫痫手术是治疗DRE的既定方法，本研究探讨了小儿癫痫手术对家庭负担的影响。
我们回顾性分析了2018年4月至2021年11月在我们癫痫中心接受癫痫手术治疗的局灶性结构性DRE家庭和小儿患者的数据。我们研究了认知、行为和癫痫特异性数据与癫痫手术前后用德文版家庭影响量表测量的家庭负担之间的关系。
研究队列包括31名DRE患儿，手术时平均年龄为9岁（范围=0-16岁），平均癫痫病程为3年（范围=0-14年）。术前DRE患儿的认知障碍与家庭负担相关。在最后一次评估时，癫痫手术后14.5个月（平均，范围=6-24个月），87.2%的患者无癫痫发作，家庭负担值下降了75.0%，行为问题下降了85.7%。癫痫手术后认知功能保持稳定。
对于DRE患儿，癫痫手术可减轻家庭负担。鉴于家庭对其子女的发育和福祉有相当大的影响，应将癫痫手术的影响告知受影响的家庭。
