系统性红斑狼疮患者合并侵袭性真菌感染的临床危险因素的荟萃分析。
Meta-analysis of clinical risk factors of patients with systemic lupus erythematosus complicated with invasive fungal infection.
机构信息
Department of Dermatology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Department of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
出版信息
Medicine (Baltimore). 2023 Mar 17;102(11):e29652. doi: 10.1097/MD.0000000000029652.
BACKGROUND
To systematically evaluate the clinical risk factors of patients with systemic lupus erythematosus (SLE) complicated with invasive fungal infection (IFI) among patients.
METHODS
A meta-analysis was performed of all the literatures germane to estimate the clinical risk factors of patients with SLE complicated with IFI from published clinical trials from 1990 to April 2022. Mean differences, odds ratio and 95% confidence intervals were calculated, and the meta-analysis was conducted with Stata 12.0 software (StataCorp, College Station, TX).
RESULTS
A total of 14 clinical research involving 1129 patients were included. The results of meta-analysis demonstrated that immunosuppressant, glucocorticoids, systemic lupus erythematosus disease activity index score, antibiotic were risk factors associated with IFI in SLE patients. However, age, sex, course of disease, leukopenia, lymphopenia, C- reactive protein and hypoproteinemia were not the risk factors associated with IFI in patients with SLE.
CONCLUSION
Our results indicate that immunosuppressant, glucocorticoids, systemic lupus erythematosus disease activity index score, antibiotic were risk factors for IFI in SLE patients. However, high quality of multicenter, large sample size-controlled trials are needed to validate the result.
背景
系统性评估系统性红斑狼疮（SLE）患者合并侵袭性真菌感染（IFI）的临床危险因素。
方法
对 1990 年至 2022 年 4 月发表的所有相关临床试验文献进行了荟萃分析，以评估 SLE 合并 IFI 患者的临床危险因素。使用 Stata 12.0 软件（StataCorp，College Station，TX）计算均值差异、比值比和 95%置信区间。
结果
共纳入 14 项临床研究，涉及 1129 例患者。荟萃分析结果表明，免疫抑制剂、糖皮质激素、系统性红斑狼疮疾病活动指数评分、抗生素是 SLE 患者发生 IFI 的危险因素。然而，年龄、性别、病程、白细胞减少、淋巴细胞减少、C 反应蛋白和低蛋白血症不是 SLE 患者发生 IFI 的危险因素。
结论
我们的研究结果表明，免疫抑制剂、糖皮质激素、系统性红斑狼疮疾病活动指数评分和抗生素是 SLE 患者发生 IFI 的危险因素。然而，需要进行高质量的多中心、大样本量对照试验来验证该结果。
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