Mahmood Muhammad Muzaffar, Nawaz Muhammad Jabran
Department of Cardiology, Ittefaq Hospital, Lahore, Pakistan.
Department of Medicine, Ittefaq Hospital, Lahore, Pakistan.
J Pak Med Assoc. 2023 Mar;73(3):646-649. doi: 10.47391/JPMA.4328.
There is limited information about the current use of high-intensity statins (HIS) after acute coronary syndrome (ACS) in Pakistani patients. We studied the prescription of HIS in patients admitted with ACS to Ittefaq Hospital, Lahore, Pakistan, from February 2019 to December 2019. Among the 411 patients, 221 (53.8%) patients underwent Percutaneous Coronary Intervention (PCI), 62 (15.1%) were referred for Coronary Artery Bypass Graft (CABG), and 128 (31.1%) were treated medically. Overall 408 (99.3%) patients were prescribed statins and 198 (48.2%) received HIS, with 45 (10.9%) patients receiving maximally allowed dose (Atorvastatin 80mg or Rosuvastatin 40mg). Patients treated with PCI were more likely to be prescribed HIS (73.3% vs 26.7%, p <0.001), while older patients (>75 years of age), those treated medically, and patients with severely reduced LV systolic function were significantly less likely to receive HIS (p <0.001). Our study, therefore, identifies a gap in implementation of guidelines for HIS use, particularly among the medically treated ACS patients.
关于巴基斯坦患者急性冠状动脉综合征(ACS)后高强度他汀类药物(HIS)的当前使用情况,信息有限。我们研究了2019年2月至2019年12月期间在巴基斯坦拉合尔伊特法克医院因ACS入院的患者中HIS的处方情况。在411例患者中,221例(53.8%)接受了经皮冠状动脉介入治疗(PCI),62例(15.1%)被转诊进行冠状动脉旁路移植术(CABG),128例(31.1%)接受药物治疗。总体而言,408例(99.3%)患者被处方使用他汀类药物,198例(48.2%)接受了HIS,其中45例(10.9%)患者接受了最大允许剂量(阿托伐他汀80mg或瑞舒伐他汀40mg)。接受PCI治疗的患者更有可能被处方使用HIS(73.3%对26.7%,p<0.001),而老年患者(>75岁)、接受药物治疗的患者以及左心室收缩功能严重降低的患者接受HIS的可能性显著降低(p<0.001)。因此,我们的研究发现了HIS使用指南实施方面的差距,特别是在接受药物治疗的ACS患者中。