1 型糖尿病患儿/青少年父母中抑郁的患病率：系统评价和荟萃分析。

The prevalence of depression among parents of children/adolescents with type 1 diabetes: A systematic review and meta-analysis.

机构信息

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.

出版信息

Front Endocrinol (Lausanne). 2023 Mar 1;14:1095729. doi: 10.3389/fendo.2023.1095729. eCollection 2023.

DOI:10.3389/fendo.2023.1095729

PMID:36936139

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10014558/

Abstract

BACKGROUND

Emerging research indicates that depression among parents of children/adolescents with type 1 diabetes mellitus (T1DM) has increased significantly. However, the prevalence rates reported by different studies vary substantially.

METHODS

Seven databases were systematically searched (Pubmed, Embase, MEDLINE, Scopus, Web of Science, Cochrane Library, PsycInfo) from the inception to 15th October 2022. We pooled prevalence rates from each study with a random-effect model. We conducted a stratified meta-analysis to identify the potential sources of heterogeneity among studies. The GRADE (Grading of Recommendations, Assessment, Development and Evaluations) approach was utilized to evaluate the quality of evidence.

RESULTS

Twenty-two studies were included, with a total of 4639 parents living with type 1 diabetic children. Overall, the pooled prevalence rate of depression or depressive symptoms was 22.4% (95%CI 17.2% to 28.7%; = 96.8%). The prevalence was higher among mothers (31.5%) than fathers (16.3%) as well as parents of children (aged < 12 years) with T1DM (32.3%) than those with adolescents (aged ≥ 12 years) (16.0%).

CONCLUSION

Our research suggests that more than 1 in 5 parents of type 1 diabetic children/adolescents worldwide suffer from depression or depressive symptom. Depression screening and interventions are required for parents of children with T1DM.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/prospero/, identifier (CRD42022368702).

摘要

背景

新出现的研究表明，1 型糖尿病患儿/青少年父母的抑郁情绪显著增加。然而，不同研究报告的患病率差异很大。

方法

从成立到 2022 年 10 月 15 日，系统地在 7 个数据库（Pubmed、Embase、MEDLINE、Scopus、Web of Science、Cochrane Library、PsycInfo）中进行了搜索。我们使用随机效应模型对每项研究的患病率进行了汇总。我们进行了分层荟萃分析，以确定研究之间潜在的异质性来源。使用 GRADE（推荐分级、评估、发展和评估）方法评估证据质量。

结果

共纳入 22 项研究，共计 4639 名与 1 型糖尿病儿童共同生活的父母。总体而言，抑郁或抑郁症状的总患病率为 22.4%（95%CI 17.2%至 28.7%； = 96.8%）。母亲（31.5%）的患病率高于父亲（16.3%），12 岁以下儿童（32.3%）的患病率高于 12 岁以上青少年（16.0%）。